Glycosylation is an important posttranslational modifier of proteins and lipid conjugates
critical for the stability and function of these macromolecules. Particularly important are N …

Background: Cancer has profound effects on gene expression, including a cell's
glycosylation machinery. Thus, tumors produce glycoproteins that carry oligosaccharides …

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, and
the cancer with the fastest increase in mortality in the United States, with more than 39,000 …

Background One of the new roles for enzymes in personalized medicine builds on a rational
approach to cancer biomarker discovery using enzyme-associated aberrant glycosylation. A …

Fucosylation is the process of transferring fucose from GDP-fucose to their substrates, which
includes certain proteins, N-and O-linked glycans in glycoprotein or glycolipids, by …

Liver cancer is the fifth most common cancer, but the second leading cause of cancer death,
in the world, with more than 700,000 fatalities annually. The major etiology of liver cancer is …

Hepatocellular carcinoma (HCC) remains as the fifth most common cancer in the world and
accounts for more than 700,000 deaths annually. Changes in serum glycosylation have long …

Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide.
Understanding the cancer mechanisms provides novel diagnostic, prognostic, and …

Nonalcoholic steatohepatitis (NASH) is rising in prevalence in the United States and is a
growing cause of hepatocellular carcinomas (HCCs). Site-specific glycan heterogeneity on …

Hepatocellular carcinoma (HCC) is the third most‐common cause of cancer‐related death
worldwide. Most cases of HCC develop in patients that already have liver cirrhosis and have …