Intrinsically disordered proteins in cellular signalling and regulation
PE Wright, HJ Dyson - Nature reviews Molecular cell biology, 2015 - nature.com
Intrinsically disordered proteins (IDPs) are important components of the cellular signalling
machinery, allowing the same polypeptide to undertake different interactions with different …
machinery, allowing the same polypeptide to undertake different interactions with different …
Machine learning meets omics: applications and perspectives
The innovation of biotechnologies has allowed the accumulation of omics data at an
alarming rate, thus introducing the era of 'big data'. Extracting inherent valuable knowledge …
alarming rate, thus introducing the era of 'big data'. Extracting inherent valuable knowledge …
Regulation of epithelial-mesenchymal transition through epigenetic and post-translational modifications
The epithelial to mesenchymal transition (EMT) is a biological process in which a non-motile
epithelial cell changes to a mesenchymal phenotype with invasive capacities. This …
epithelial cell changes to a mesenchymal phenotype with invasive capacities. This …
Biological importance of arginine: A comprehensive review of the roles in structure, disorder, and functionality of peptides and proteins
Abstract Arginine shows Jekyll and Hyde behavior in several respects. It participates in
protein folding via ionic and H-bonds and cation-pi interactions; the charge and …
protein folding via ionic and H-bonds and cation-pi interactions; the charge and …
MusiteDeep: a deep-learning based webserver for protein post-translational modification site prediction and visualization
MusiteDeep is an online resource providing a deep-learning framework for protein post-
translational modification (PTM) site prediction and visualization. The predictor only uses …
translational modification (PTM) site prediction and visualization. The predictor only uses …
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …
Since then, this topic has received increasing attention, and many scientists have entered …
Deep learning in proteomics
Proteomics, the study of all the proteins in biological systems, is becoming a data‐rich
science. Protein sequences and structures are comprehensively catalogued in online …
science. Protein sequences and structures are comprehensively catalogued in online …
Mechanistic insights into mammalian stress granule dynamics
The accumulation of stalled translation preinitiation complexes (PICs) mediates the
condensation of stress granules (SGs). Interactions between prion-related domains and …
condensation of stress granules (SGs). Interactions between prion-related domains and …
More than a marker: potential pathogenic functions of MAP2
Microtubule-associated protein 2 (MAP2) is the predominant cytoskeletal regulator within
neuronal dendrites, abundant and specific enough to serve as a robust somatodendritic …
neuronal dendrites, abundant and specific enough to serve as a robust somatodendritic …
Intrinsic disorder and posttranslational modifications: the darker side of the biological dark matter
AL Darling, VN Uversky - Frontiers in genetics, 2018 - frontiersin.org
Intrinsically disordered proteins (IDPs) and intrinsically disordered protein regions (IDPRs)
are functional proteins and domains that devoid stable secondary and/or tertiary structure …
are functional proteins and domains that devoid stable secondary and/or tertiary structure …