Genome control by SMC complexes
C Hoencamp, BD Rowland - Nature Reviews Molecular Cell Biology, 2023 - nature.com
Many cellular processes require large-scale rearrangements of chromatin structure.
Structural maintenance of chromosomes (SMC) protein complexes are molecular machines …
Structural maintenance of chromosomes (SMC) protein complexes are molecular machines …
Loo** the genome with SMC complexes
SMC (structural maintenance of chromosomes) protein complexes are an evolutionarily
conserved family of motor proteins that hold sister chromatids together and fold genomes …
conserved family of motor proteins that hold sister chromatids together and fold genomes …
The Smc5/6 complex is a DNA loop-extruding motor
B Pradhan, T Kanno, M Umeda Igarashi, MS Loke… - Nature, 2023 - nature.com
Structural maintenance of chromosomes (SMC) protein complexes are essential for the
spatial organization of chromosomes. Whereas cohesin and condensin organize …
spatial organization of chromosomes. Whereas cohesin and condensin organize …
CTCF is a DNA-tension-dependent barrier to cohesin-mediated loop extrusion
In eukaryotes, genomic DNA is extruded into loops by cohesin. By restraining this process,
the DNA-binding protein CCCTC-binding factor (CTCF) generates topologically associating …
the DNA-binding protein CCCTC-binding factor (CTCF) generates topologically associating …
All eukaryotic SMC proteins induce a twist of− 0.6 at each DNA loop extrusion step
Eukaryotes carry three types of structural maintenance of chromosome (SMC) protein
complexes, condensin, cohesin, and SMC5/6, which are ATP-dependent motor proteins that …
complexes, condensin, cohesin, and SMC5/6, which are ATP-dependent motor proteins that …
A hold-and-feed mechanism drives directional DNA loop extrusion by condensin
IA Shaltiel, S Datta, L Lecomte, M Hassler… - Science, 2022 - science.org
Structural maintenance of chromosomes (SMC) protein complexes structure genomes by
extruding DNA loops, but the molecular mechanism that underlies their activity has …
extruding DNA loops, but the molecular mechanism that underlies their activity has …
[HTML][HTML] SMC complexes can traverse physical roadblocks bigger than their ring size
Ring-shaped structural maintenance of chromosomes (SMC) complexes like condensin and
cohesin extrude loops of DNA. It remains, however, unclear how they can extrude DNA …
cohesin extrude loops of DNA. It remains, however, unclear how they can extrude DNA …
A walk through the SMC cycle: From catching DNAs to sha** the genome
R Oldenkamp, BD Rowland - Molecular cell, 2022 - cell.com
SMC protein complexes are molecular machines that provide structure to chromosomes.
These complexes bridge DNA elements and by doing so build DNA loops in cis and hold …
These complexes bridge DNA elements and by doing so build DNA loops in cis and hold …
DNA packaging by molecular motors: from bacteriophage to human chromosomes
Dense packaging of genomic DNA is crucial for organismal survival, as DNA length always
far exceeds the dimensions of the cells that contain it. Organisms, therefore, use …
far exceeds the dimensions of the cells that contain it. Organisms, therefore, use …
Chromosome compaction is triggered by an autonomous DNA-binding module within condensin
A Pastic, ML Nosella, A Kochhar, ZH Liu… - Cell Reports, 2024 - cell.com
The compaction of chromatin into mitotic chromosomes is essential for faithful transmission
of the genome during cell division. In eukaryotes, chromosome morphogenesis is regulated …
of the genome during cell division. In eukaryotes, chromosome morphogenesis is regulated …