Maternal autoantibody related autism: mechanisms and pathways

KL Jones, J Van de Water - Molecular psychiatry, 2019 - nature.com
It has been estimated that autism spectrum disorder (ASD) now affects 1 in 59 children in the
United States. Although the cause (s) of ASD remain largely unknown, it is becoming …

Repetitive mild traumatic brain injury in mice triggers a slowly develo** cascade of long-term and persistent behavioral deficits and pathological changes

X Xu, M Cowan, F Beraldo, A Schranz… - Acta neuropathologica …, 2021 - Springer
We have previously reported long-term changes in the brains of non-concussed varsity
rugby players using magnetic resonance spectroscopy (MRS), diffusion tensor imaging (DTI) …

Risk assessment analysis for maternal autoantibody-related autism (MAR-ASD): a subtype of autism

A Ramirez-Celis, M Becker, M Nuño, J Schauer… - Molecular …, 2021 - nature.com
The incidence of autism spectrum disorder (ASD) has been rising, however ASD-risk
biomarkers remain lacking. We previously identified the presence of maternal …

Hsp70/Hsp90 organising protein (Hop): coordinating much more than chaperones

K Schwarz, S Baindur-Hudson, GL Blatch… - The Networking of …, 2022 - Springer
Abstract The Hsp70/Hsp90 organising protein (Hop, also known as stress-inducible protein
1/STI1/STIP1) has received considerable attention for diverse cellular functions in both …

Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo

RE Lackie, AS de Miranda, MP Lim, V Novikov… - Acta …, 2022 - Springer
The predominantly pre-synaptic intrinsically disordered protein α-synuclein is prone to
misfolding and aggregation in synucleinopathies, such as Parkinson's disease (PD) and …

Maternal autoantibody profiles as biomarkers for ASD and ASD with co-occurring intellectual disability

A Ramirez-Celis, LA Croen, CK Yoshida… - Molecular …, 2022 - nature.com
Maternal autoantibody-related ASD (MAR ASD) is a subtype of autism in which pathogenic
maternal autoantibodies (IgG) cross the placenta, access the develo** brain, and cause …

MouseBytes, an open-access high-throughput pipeline and database for rodent touchscreen-based cognitive assessment

FH Beraldo, D Palmer, S Memar, DI Wasserman… - Elife, 2019 - elifesciences.org
Open Science has changed research by making data accessible and shareable,
contributing to replicability to accelerate and disseminate knowledge. However, for rodent …

Chronic hM3Dq signaling in microglia ameliorates neuroinflammation in male mice

W Binning, AE Hogan-Cann, DY Sakae… - Brain, Behavior, and …, 2020 - Elsevier
Microglia express muscarinic G protein-coupled receptors (GPCRs) that sense cholinergic
activity and are activated by acetylcholine to potentially regulate microglial functions …

Novel therapeutic targets for major depressive disorder related to oxidative stress identified by integrative multi-omics and multi-trait study

X Shao, Y Wang, Z Geng, G Liang, X Zhu, L Liu… - Translational …, 2024 - nature.com
Oxidative stress (OS) is strongly implicated in the pathophysiology of major depressive
disorder (MDD) but the molecular mechanisms remain largely unknown. The purpose of this …

Neonatal erythropoietin mitigates impaired gait, social interaction and diffusion tensor imaging abnormalities in a rat model of prenatal brain injury

S Robinson, CJ Corbett, JL Winer, LAS Chan… - Experimental …, 2018 - Elsevier
Children who are born preterm are at risk for encephalopathy of prematurity, a leading
cause of cerebral palsy, cognitive delay and behavioral disorders. Current interventions are …