Synthesis, functionalization, and design of magnetic nanoparticles for theranostic applications

J Mosayebi, M Kiyasatfar… - Advanced Healthcare …, 2017 - Wiley Online Library
In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs)
have been presented as a class of non‐invasive nanomaterials for numerous biomedical …

Cell-penetrating peptides to enhance delivery of oligonucleotide-based therapeutics

G McClorey, S Banerjee - Biomedicines, 2018 - mdpi.com
The promise of nucleic acid based oligonucleotides as effective genetic therapies has been
held back by their low bioavailability and poor cellular uptake to target tissues upon systemic …

3D printing polymers with supramolecular functionality for biological applications

AM Pekkanen, RJ Mondschein, CB Williams… - …, 2017 - ACS Publications
Supramolecular chemistry continues to experience widespread growth, as fine-tuned
chemical structures lead to well-defined bulk materials. Previous literature described the …

Approaches for evaluation of novel CPP-based cargo delivery systems

L Porosk, Ü Langel - Frontiers in Pharmacology, 2022 - frontiersin.org
Cell penetrating peptides (CPPs) can be broadly defined as relatively short synthetic, protein
derived or chimeric peptides. Their most remarkable property is their ability to cross cell …

Versatility of cell-penetrating peptides for intracellular delivery of siRNA

T Singh, ASN Murthy, HJ Yang, J Im - Drug delivery, 2018 - Taylor & Francis
The plasma membrane is a large barrier to systemic drug delivery into cells, and it limits the
efficacy of drug cargo. This issue has been overcome using cell-penetrating peptides …

The formation of nanoparticles between small interfering RNA and amphipathic cell-penetrating peptides

L Pärnaste, P Arukuusk, K Langel, T Tenson… - … Therapy Nucleic Acids, 2017 - cell.com
Cell-penetrating peptides (CPPs) are delivery vectors widely used to aid the transport of
biologically active cargoes to intracellular targets. These cargoes include small interfering …

Optimization of in vivo DNA delivery with NickFect peptide vectors

K Freimann, P Arukuusk, K Kurrikoff… - Journal of Controlled …, 2016 - Elsevier
As the field of gene therapy progresses, an increasingly urgent need has arisen for efficient
and non-toxic vectors for the in vivo delivery of nucleic acids. Cell-penetrating peptides …

Saturated fatty acid analogues of cell-penetrating peptide PepFect14: role of fatty acid modification in complexation and delivery of splice-correcting oligonucleotides

T Lehto, L Vasconcelos, H Margus… - Bioconjugate …, 2017 - ACS Publications
Modifying cell-penetrating peptides (CPPs) with fatty acids has long been used to improve
peptide-mediated nucleic acid delivery. In this study we have revisited this phenomenon …

[HTML][HTML] Peptide-assisted nucleic acid delivery systems on the rise

S Tarvirdipour, M Skowicki… - International Journal of …, 2021 - mdpi.com
Concerns associated with nanocarriers' therapeutic efficacy and side effects have led to the
development of strategies to advance them into targeted and responsive delivery systems …

Enhancement of siRNA transfection by the optimization of fatty acid length and histidine content in the CPP

L Porosk, P Arukuusk, K Põhako, K Kurrikoff… - Biomaterials …, 2019 - pubs.rsc.org
Extracellular synthetic nucleic acids, such as siRNAs, are unable to reach their intended
targets efficiently. Therefore, delivery methods such as cell-penetrating peptides (CPP) …