Investigations of apolipoprotein E (APOE) gene, the major genetic risk modifier for
Alzheimer's disease (AD), have yielded significant insights into the pathogenic mechanism …

Imaging genetics offers the possibility of detecting associations between genotype and brain
structure as well as function, with effect sizes potentially exceeding correlations between …

Reduction in hippocampal and amygdala volume measured via structural magnetic
resonance imaging is an early marker of Alzheimer's disease (AD). Whether genetic risk …

Background Recent genome-wide association studies have identified genetic loci that jointly
make a considerable contribution to risk of develo** Alzheimer's disease (AD). Because …

The ε4 allele of the apolipoprotein E (APOE4) is associated with an increased risk of
develo** Alzheimer's disease (AD). Hence, several studies have compared the brain …

The last decade has witnessed a proliferation of neuroimaging studies characterising brain
changes associated with Alzheimer's disease (AD), where both widespread atrophy and …

Whether novel risk variants of Alzheimer's disease (AD) identified through genome-wide
association studies also influence magnetic resonance imaging-based intermediate …

Objective: The aims of the current study were to determine whether children with the 6
different APOE ε genotypes show differences in gray matter maturation, particularly for those …

Objective: Alzheimer's disease is a heritable neurodegenerative disorder in which early-life
precursors may manifest in cognition and brain structure. The authors evaluate this …

Genetic risk factors such as APOE ε4 and MAPT (rs242557) A allele are associated with
amyloid and tau pathways and grey matter changes at both early and established stages of …