Abandon the mouse research ship? Not just yet!
Many preclinical studies in critical care medicine and related disciplines rely on hypothesis-
driven research in mice. The underlying premise posits that mice sufficiently emulate …
driven research in mice. The underlying premise posits that mice sufficiently emulate …
Evaluation of vitamin C for adjuvant sepsis therapy
JX Wilson - Antioxidants & redox signaling, 2013 - liebertpub.com
Significance: Evidence is emerging that parenteral administration of high-dose vitamin C
may warrant development as an adjuvant therapy for patients with sepsis. Recent Advances …
may warrant development as an adjuvant therapy for patients with sepsis. Recent Advances …
Bacterial pathogens activate plasminogen to breach tissue barriers and escape from innate immunity
M Peetermans, T Vanassche… - Critical reviews in …, 2016 - Taylor & Francis
Both coagulation and fibrinolysis are tightly connected with the innate immune system.
Infection and inflammation cause profound alterations in the otherwise well-controlled …
Infection and inflammation cause profound alterations in the otherwise well-controlled …
Mitochondria‐targeted antioxidants SkQ1 and mitoTEMPO failed to exert a long‐term beneficial effect in murine polymicrobial sepsis
Mitochondrial‐derived reactive oxygen species have been deemed an important contributor
in sepsis pathogenesis. We investigated whether two mitochondria‐targeted antioxidants …
in sepsis pathogenesis. We investigated whether two mitochondria‐targeted antioxidants …
[HTML][HTML] Toll‐like receptors 2 and 7 mediate coagulation activation and coagulopathy in murine sepsis
Background Sepsis is a life‐threatening condition often manifested as marked inflammation
and severe coagulopathy. Toll‐like receptors (TLRs) play a pivotal role in inflammation …
and severe coagulopathy. Toll‐like receptors (TLRs) play a pivotal role in inflammation …
Why do they die? Comparison of selected aspects of organ injury and dysfunction in mice surviving and dying in acute abdominal sepsis
Background The mechanisms of sepsis mortality remain undefined. While there is some
evidence of organ damage, it is not clear whether this damage alone is sufficient to cause …
evidence of organ damage, it is not clear whether this damage alone is sufficient to cause …
Visceral fat‐specific regulation of plasminogen activator inhibitor‐1 in aged septic mice
Elevated plasma levels of plasminogen activator inhibitor‐1 (PAI‐1) are documented in
patients with sepsis and levels positively correlate with disease severity and mortality. Our …
patients with sepsis and levels positively correlate with disease severity and mortality. Our …
Remarkable stabilization of plasminogen activator inhibitor 1 in a “molecular sandwich” complex
Plasminogen activator inhibitor 1 (PAI-1) levels are elevated in a number of life-threatening
conditions and often correlate with unfavorable outcomes. Spontaneous inactivation due to …
conditions and often correlate with unfavorable outcomes. Spontaneous inactivation due to …
Delayed activation of PPAR-β/δ improves long-term survival in mouse sepsis: effects on organ inflammation and coagulation
D Busch, A Kapoor, P Rademann… - Innate …, 2018 - journals.sagepub.com
Activation of peroxisome proliferator-activated receptor (PPAR)-β/δ reduces tissue injury in
murine endotoxemia. We hypothesized that the PPAR-β/δ-agonist GW0742 improves long …
murine endotoxemia. We hypothesized that the PPAR-β/δ-agonist GW0742 improves long …
[HTML][HTML] Systemic inhibition and liver‐specific over‐expression of PAI‐1 failed to improve survival in all‐inclusive populations or homogenous cohorts of CLP mice
P Raeven, S Drechsler, KM Weixelbaumer… - Journal of Thrombosis …, 2014 - Elsevier
Background The role of plasminogen activator inhibitor type‐1 (PAI‐1) in abdominal sepsis
remains elusive. Objectives To study the influence of inhibition and over‐expression of PAI …
remains elusive. Objectives To study the influence of inhibition and over‐expression of PAI …