Network pharmacology applications to map the unexplored target space and therapeutic potential of natural products

M Kibble, N Saarinen, J Tang, K Wennerberg… - Natural product …, 2015 - pubs.rsc.org
Covering: 2011 to 2014 It is widely accepted that drug discovery often requires a systems-
level polypharmacology approach to tackle problems such as lack of efficacy and emerging …

Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review

P Csermely, T Korcsmáros, HJM Kiss, G London… - Pharmacology & …, 2013 - Elsevier
Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

Comparative Toxicogenomics Database: a knowledgebase and discovery tool for chemical–gene–disease networks

AP Davis, CG Murphy… - Nucleic acids …, 2009 - academic.oup.com
Abstract The Comparative Toxicogenomics Database (CTD) is a curated database that
promotes understanding about the effects of environmental chemicals on human health …

On the selection of appropriate distances for gene expression data clustering

PA Jaskowiak, RJGB Campello, IG Costa - BMC bioinformatics, 2014 - Springer
Background Clustering is crucial for gene expression data analysis. As an unsupervised
exploratory procedure its results can help researchers to gain insights and formulate new …

[HTML][HTML] Omic techniques in systems biology approaches to traditional Chinese medicine research: present and future

A Buriani, ML Garcia-Bermejo, E Bosisio, Q Xu… - Journal of …, 2012 - Elsevier
Omic techniques have become key tools in the development of systems biology. As the
holistic approaches underlying the practice of traditional Chinese medicine (TCM) and new …

The Consortium for Metabonomic Toxicology (COMET): aims, activities and achievements

JC Lindon, HC Keun, TMD Ebbels, JMT Pearce… - …, 2005 - Taylor & Francis
The utility of metabonomics in the evaluation of xenobiotic toxicity has been
comprehensively assessed by the Consortium for Metabonomic Toxicology (COMET) …

The Japanese toxicogenomics project: application of toxicogenomics

T Uehara, A Ono, T Maruyama, I Kato… - Molecular nutrition & …, 2010 - Wiley Online Library
Biotechnology advances have provided novel methods for the risk assessment of chemicals.
The application of microarray technologies to toxicology, known as toxicogenomics, is …

A decade of toxicogenomic research and its contribution to toxicological science

M Chen, M Zhang, J Borlak, W Tong - Toxicological Sciences, 2012 - academic.oup.com
Toxicogenomics enjoyed considerable attention as a ground-breaking addition to
conventional toxicology assays at its inception. However, the pace at which toxicogenomics …

The evolution of bioinformatics in toxicology: advancing toxicogenomics

CA Afshari, HK Hamadeh, PR Bushel - Toxicological Sciences, 2011 - academic.oup.com
As one reflects back through the past 50 years of scientific research, a significant
accomplishment was the advance into the genomic era. Basic research scientists have …

CEBS—Chemical Effects in Biological Systems: a public data repository integrating study design and toxicity data with microarray and proteomics data

M Waters, S Stasiewicz, B Alex Merrick… - Nucleic acids …, 2007 - academic.oup.com
Abstract CEBS (Chemical Effects in Biological Systems) is an integrated public repository for
toxicogenomics data, including the study design and timeline, clinical chemistry and …