Network pharmacology applications to map the unexplored target space and therapeutic potential of natural products
Covering: 2011 to 2014 It is widely accepted that drug discovery often requires a systems-
level polypharmacology approach to tackle problems such as lack of efficacy and emerging …
level polypharmacology approach to tackle problems such as lack of efficacy and emerging …
Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review
Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …
methods and in rational drug design, the increase in approved drugs in the past decade did …
Comparative Toxicogenomics Database: a knowledgebase and discovery tool for chemical–gene–disease networks
AP Davis, CG Murphy… - Nucleic acids …, 2009 - academic.oup.com
Abstract The Comparative Toxicogenomics Database (CTD) is a curated database that
promotes understanding about the effects of environmental chemicals on human health …
promotes understanding about the effects of environmental chemicals on human health …
On the selection of appropriate distances for gene expression data clustering
Background Clustering is crucial for gene expression data analysis. As an unsupervised
exploratory procedure its results can help researchers to gain insights and formulate new …
exploratory procedure its results can help researchers to gain insights and formulate new …
[HTML][HTML] Omic techniques in systems biology approaches to traditional Chinese medicine research: present and future
Omic techniques have become key tools in the development of systems biology. As the
holistic approaches underlying the practice of traditional Chinese medicine (TCM) and new …
holistic approaches underlying the practice of traditional Chinese medicine (TCM) and new …
The Consortium for Metabonomic Toxicology (COMET): aims, activities and achievements
The utility of metabonomics in the evaluation of xenobiotic toxicity has been
comprehensively assessed by the Consortium for Metabonomic Toxicology (COMET) …
comprehensively assessed by the Consortium for Metabonomic Toxicology (COMET) …
The Japanese toxicogenomics project: application of toxicogenomics
Biotechnology advances have provided novel methods for the risk assessment of chemicals.
The application of microarray technologies to toxicology, known as toxicogenomics, is …
The application of microarray technologies to toxicology, known as toxicogenomics, is …
A decade of toxicogenomic research and its contribution to toxicological science
Toxicogenomics enjoyed considerable attention as a ground-breaking addition to
conventional toxicology assays at its inception. However, the pace at which toxicogenomics …
conventional toxicology assays at its inception. However, the pace at which toxicogenomics …
The evolution of bioinformatics in toxicology: advancing toxicogenomics
CA Afshari, HK Hamadeh, PR Bushel - Toxicological Sciences, 2011 - academic.oup.com
As one reflects back through the past 50 years of scientific research, a significant
accomplishment was the advance into the genomic era. Basic research scientists have …
accomplishment was the advance into the genomic era. Basic research scientists have …
CEBS—Chemical Effects in Biological Systems: a public data repository integrating study design and toxicity data with microarray and proteomics data
Abstract CEBS (Chemical Effects in Biological Systems) is an integrated public repository for
toxicogenomics data, including the study design and timeline, clinical chemistry and …
toxicogenomics data, including the study design and timeline, clinical chemistry and …