Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx/atrogin-1
Muscle RING finger 1 (MuRF1) and muscle atrophy F-box (MAFbx)/atrogin-1 were identified
more than 10 years ago as two muscle-specific E3 ubiquitin ligases that are increased …
more than 10 years ago as two muscle-specific E3 ubiquitin ligases that are increased …
Signaling pathways that control muscle mass
The loss of skeletal muscle mass under a wide range of acute and chronic maladies is
associated with poor prognosis, reduced quality of life, and increased mortality. Decades of …
associated with poor prognosis, reduced quality of life, and increased mortality. Decades of …
[HTML][HTML] Mechanisms regulating neuromuscular junction development and function and causes of muscle wasting
LA Tintignac, HR Brenner… - Physiological …, 2015 - journals.physiology.org
The neuromuscular junction is the chemical synapse between motor neurons and skeletal
muscle fibers. It is designed to reliably convert the action potential from the presynaptic …
muscle fibers. It is designed to reliably convert the action potential from the presynaptic …
Disuse-induced muscle wasting
SC Bodine - The international journal of biochemistry & cell biology, 2013 - Elsevier
Loss of skeletal muscle mass occurs frequently in clinical settings in response to joint
immobilization and bed rest, and is induced by a combination of unloading and inactivity …
immobilization and bed rest, and is induced by a combination of unloading and inactivity …
Stain-Free total protein staining is a superior loading control to β-actin for Western blots
JE Gilda, AV Gomes - Analytical biochemistry, 2013 - Elsevier
Semi-quantification of proteins using Western blots typically involves normalization against
housekee** genes such as β-actin. More recently, Ponceau S and Coomassie blue …
housekee** genes such as β-actin. More recently, Ponceau S and Coomassie blue …
BMP signaling controls muscle mass
R Sartori, E Schirwis, B Blaauw, S Bortolanza, J Zhao… - Nature …, 2013 - nature.com
Cell size is determined by the balance between protein synthesis and degradation. This
equilibrium is affected by hormones, nutrients, energy levels, mechanical stress and …
equilibrium is affected by hormones, nutrients, energy levels, mechanical stress and …
Protein damage, repair and proteolysis
N Chondrogianni, I Petropoulos, S Grimm… - Molecular aspects of …, 2014 - Elsevier
Proteins are continuously affected by various intrinsic and extrinsic factors. Damaged
proteins influence several intracellular pathways and result in different disorders and …
proteins influence several intracellular pathways and result in different disorders and …
Control of skeletal muscle atrophy in response to disuse: clinical/preclinical contentions and fallacies of evidence
Muscle wasting resulting wholly or in part from disuse represents a serious medical
complication that, when prolonged, can increase morbidity and mortality. Although much …
complication that, when prolonged, can increase morbidity and mortality. Although much …
Molecular mechanism of sarcopenia and cachexia: recent research advances
K Sakuma, W Aoi, A Yamaguchi - Pflügers Archiv-European Journal of …, 2017 - Springer
Skeletal muscle provides a fundamental basis for human function, enabling locomotion and
respiration. Muscle loss occurs as a consequence of several chronic diseases (cachexia) …
respiration. Muscle loss occurs as a consequence of several chronic diseases (cachexia) …
Muscle wasting in cancer
Skeletal muscle loss appears to be the most significant clinical event in cancer cachexia and
is associated with a poor outcome. With regard to such muscle loss, despite extensive study …
is associated with a poor outcome. With regard to such muscle loss, despite extensive study …