Hereditary spastic paraplegia (HSP) is a group of clinically and genetically heterogeneous
neurological disorders characterized by pathophysiologic hallmark of length-dependent …

Hereditary spastic paraplegia comprises a wide and heterogeneous group of inherited
neurodegenerative and neurodevelopmental disorders resulting from primary retrograde …

Neurodegeneration with brain iron accumulation (NBIA) comprises a clinically and
genetically heterogeneous group of disorders affecting children and adults. These rare …

Hereditary spastic paraplegias (HSP) are a heterogeneous group of motor
neurodegenerative disorders that have the core clinical presentation of pyramidal syndrome …

The hereditary spastic paraplegias (HSPs) are a heterogeneous group of neurologic
disorders with the common feature of prominent lower-extremity spasticity, resulting from a …

Hereditary spastic paraplegias (HSPs) are genetically determined neurodegenerative
disorders characterized by progressive weakness and spasticity of lower limbs, and are …

Perturbation of iron distribution is observed in many neurodegenerative disorders, including
Alzheimer's and Parkinson's disease, but the comprehension of the metal role in the …

Introduction The inability of some seriously and chronically ill individuals to receive a
definitive diagnosis represents an unmet medical need. In 2008, the NIH Undiagnosed …

The syndromes of neurodegeneration with brain iron accumulation (NBIA) encompass a
group of invalidating and progressive rare diseases that share the abnormal accumulation of …

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