Calcium signaling underlies much of physiology. Almost all the Ca2+ in the cytoplasm is
bound to buffers, with typically only∼ 1% being freely ionized at resting levels in most cells …

Transient rises in the cytoplasmic concentration of calcium ions serve as second messenger
signals that control many neuronal functions. Selective triggering of these functions is …

Taking a step-by-step approach to modelling neurons and neural circuitry, this textbook
teaches students how to use computational techniques to understand the nervous system at …

Increases in intracellular calcium concentration are required for the release of
neurotransmitter from presynaptic terminals in all neurons. However, the mechanism by …

RAPID calcium-dependent exocytosis underlies neurotransmitter release from nerve
terminals. Despite the fundamental importance of this process, neither the relationship …

Little is known about the physiology of neurons in Caenorhabditis elegans. Using new
techniques for in situ patch-clamp recording in C. elegans, we analyzed the electrical …

At the presynaptic active zone, Ca 2+ influx triggers fusion of synaptic vesicles. It is not well
understood how Ca 2+ channel clustering and synaptic vesicle docking are organized …

COMMUNICATION among neurons occurs at specialized synaptic junctions, where
neurotransmitter is released via calcium-dependent exocytosis from the synaptic terminal of …

Recent investigations have demonstrated that neurons have a number of different types of
calcium channels, each with their own unique properties and pharmacology. These calcium …

Hearing relies on faithful sound coding at hair cell ribbon synapses, which use Ca2+-
triggered glutamate release to signal with submillisecond precision. Here, we investigated …