Mining electronic health records: towards better research applications and clinical care

PB Jensen, LJ Jensen, S Brunak - Nature Reviews Genetics, 2012 - nature.com
Clinical data describing the phenotypes and treatment of patients represents an underused
data source that has much greater research potential than is currently realized. Mining of …

A review of approaches to identifying patient phenotype cohorts using electronic health records

C Shivade, P Raghavan… - Journal of the …, 2014 - academic.oup.com
Objective To summarize literature describing approaches aimed at automatically identifying
patients with a common phenotype. Materials and methods We performed a review of …

Retain: An interpretable predictive model for healthcare using reverse time attention mechanism

E Choi, MT Bahadori, J Sun, J Kulas… - Advances in neural …, 2016 - proceedings.neurips.cc
Accuracy and interpretability are two dominant features of successful predictive models.
Typically, a choice must be made in favor of complex black box models such as recurrent …

Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data

JC Denny, L Bastarache, MD Ritchie, RJ Carroll… - Nature …, 2013 - nature.com
Candidate gene and genome-wide association studies (GWAS) have identified genetic
variants that modulate risk for human disease; many of these associations require further …

Association of metabolic surgery with major adverse cardiovascular outcomes in patients with type 2 diabetes and obesity

A Aminian, A Zajichek, DE Arterburn, KE Wolski… - Jama, 2019 - jamanetwork.com
Importance Although metabolic surgery (defined as procedures that influence metabolism by
inducing weight loss and altering gastrointestinal physiology) significantly improves …

Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations

T Ge, MR Irvin, A Patki, V Srinivasasainagendra… - Genome Medicine, 2022 - Springer
Abstract Background Type 2 diabetes (T2D) is a worldwide scourge caused by both genetic
and environmental risk factors that disproportionately afflicts communities of color …