[HTML][HTML] Therapeutic benefits of Carica papaya: A review on its pharmacological activities and characterization of papain
BA Babalola, AI Akinwande, AA Otunba… - Arabian Journal of …, 2024 - Elsevier
Carica papaya, commonly referred to as papaya, is a member of the Caricaceae family,
boasting a diverse array of compounds and biomolecules, notably papain, with significant …
boasting a diverse array of compounds and biomolecules, notably papain, with significant …
Inhibitors of SARS-CoV-2 main protease (Mpro) as anti-coronavirus agents
The main protease (Mpro) of SARS-CoV-2 is an essential enzyme that plays a critical part in
the virus's life cycle, making it a significant target for develo** antiviral drugs. The …
the virus's life cycle, making it a significant target for develo** antiviral drugs. The …
Synthesis, in vitro α-glucosidase, α-amylase inhibitory potentials and molecular docking study of benzimidazole bearing sulfonamide analogues
We synthesized fourteen benzimidazole-containing sulfonamide analogs (1–14),
characterized them using methods including NMR and HR-EIMS. The synthesized analogs …
characterized them using methods including NMR and HR-EIMS. The synthesized analogs …
Synthesis, biological evaluation and molecular docking study of indazole based schiff base analogues as new anti-diabetic inhibitors
Indazole-based Schiff base analogues (1–27) were synthesized by a three-step reaction
pathway starting from 1-methyl-1H-indazole-3-carboxylic acid as the basic compound. The …
pathway starting from 1-methyl-1H-indazole-3-carboxylic acid as the basic compound. The …
Structural and dynamics insights into the GBA variants associated with Parkinson's disease
The GBA1 gene encodes for the lysosomal enzyme glucocerebrosidase (GCase), which
maintains glycosphingolipid homeostasis and regulates the autophagy process. Genomic …
maintains glycosphingolipid homeostasis and regulates the autophagy process. Genomic …
Synthesis, in vitro α-glucosidase and α-amylase activities, and an in silico molecular docking study of triazinoindole-thiazolidinone hybrid derivatives
Abstract Triazinoindole-thiazolidinone hybrid derivatives (1–10) was synthesised and
evaluated them against α-glucosidase and α-amylase enzymes. All synthesised derivatives …
evaluated them against α-glucosidase and α-amylase enzymes. All synthesised derivatives …
Identification of Drug Targets and Their Inhibitors in Yersinia pestis Strain 91001 through Subtractive Genomics, Machine Learning, and MD Simulation Approaches
Yersinia pestis, the causative agent of plague, is a Gram-negative bacterium. If the plague is
not properly treated it can cause rapid death of the host. Bubonic, pneumonic, and …
not properly treated it can cause rapid death of the host. Bubonic, pneumonic, and …
Develo** a SARS-CoV-2 main protease binding prediction random forest model for drug repurposing for COVID-19 treatment
The coronavirus disease 2019 (COVID-19) global pandemic resulted in millions of people
becoming infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
becoming infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
[HTML][HTML] Cysteine proteases from plants: Utilization in foods and nutraceuticals and characterization approaches for quality management
I Benito-Vázquez, M Garrido-Romero… - Applied Food …, 2024 - Elsevier
In recent years, the demand for plant-based products has emerged driven by consumers'
desire for natural options that reduce their environmental footprint. Plant proteases, which …
desire for natural options that reduce their environmental footprint. Plant proteases, which …
Structure-based virtual screening and molecular docking approaches to identify potential inhibitors against KIF2C to combat glioma
Glioma, a kind of malignant brain tumor, is extremely lethal. Kinesin family member 2C
(KIF2C) was found to have an aberrant expression in several cancer types, including lung …
(KIF2C) was found to have an aberrant expression in several cancer types, including lung …