The laminins are a family of glycoproteins that provide an integral part of the structural
scaffolding of basement membranes in almost every animal tissue. Each laminin is a …

A simplification of the laminin nomenclature is presented. Laminins are multidomain
heterotrimers composed of α, β and γ chains. Previously, laminin trimers were numbered …

Structural changes in the extracellular matrix are necessary for cell migration during tissue
remodeling and tumor invasion. Specific cleavage of laminin-5 (Ln-5) by matrix …

In patients with hepatocellular carcinoma (HCC) receiving sorafenib, drug resistance is
common. HCC develops in a microenvironment enriched with extracellular matrix proteins …

In patients with compensated advanced chronic liver disease (cACLD), the presence of
clinically significant portal hypertension (CSPH) and varices needing treatment (VNT) bears …

▪ Abstract Significant advances have been made in the application of genetics to probe the
functions of basement membrane laminins. These studies have shown that different laminin …

Laminins are large molecular weight glycoproteins constituted by the assembly of three
disulfide-linked polypeptides, the α, β and γ chains. The human genome encodes 11 …

Human skin consists of a stratified, cellular epidermis and an underlying dermis of
connective tissue [1–5]. The dermal–epidermal junction is undulating in section; ridges of …

To form a diffusible interface large enough to conduct respiratory gas exchange with the
circulation, the lung endoderm undergoes extensive branching morphogenesis and …

Basement membranes provide structural support to epithelium, endothelium, muscles, fat
cells, Schwann cells, and axons. Basement membranes are multifunctional: they modulate …