Basement membranes provide structural support to epithelium, endothelium, muscles, fat
cells, Schwann cells, and axons. Basement membranes are multifunctional: they modulate …

Laminins are large molecular weight glycoproteins constituted by the assembly of three
disulfide-linked polypeptides, the α, β and γ chains. The human genome encodes 11 …

In patients with hepatocellular carcinoma (HCC) receiving sorafenib, drug resistance is
common. HCC develops in a microenvironment enriched with extracellular matrix proteins …

The laminins are a family of glycoproteins that provide an integral part of the structural
scaffolding of basement membranes in almost every animal tissue. Each laminin is a …

A simplification of the laminin nomenclature is presented. Laminins are multidomain
heterotrimers composed of α, β and γ chains. Previously, laminin trimers were numbered …

The superficial epidermis is a stratified epithelium largely composed of keratinocytes that are
formed by division of cells in the basal layer, and give rise to several distinguishable layers …

Structural changes in the extracellular matrix are necessary for cell migration during tissue
remodeling and tumor invasion. Specific cleavage of laminin-5 (Ln-5) by matrix …

▪ Abstract Significant advances have been made in the application of genetics to probe the
functions of basement membrane laminins. These studies have shown that different laminin …

The corneal epithelial basement membrane (BM) is positioned between basal epithelial
cells and the stroma. This highly specialized extracellular matrix functions not only to anchor …

Developmental lung biology is a field that has the potential for significant human impact:
lung disease at the extremes of age continues to cause major morbidity and mortality …