A central function of the vascular endothelium is to serve as a barrier between the blood and
the surrounding tissue of the body. At the same time, solutes and cells have to pass the …

Breakdown of the inner endothelial blood-retinal barrier (BRB), as occurs in diabetic
retinopathy, age-related macular degeneration, retinal vein occlusions, uveitis and other …

The microvascular endothelial cell monolayer localized at the critical interface between the
blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying …

The endothelium functions as a semipermeable barrier regulating tissue fluid homeostasis
and transmigration of leukocytes and providing essential nutrients across the vessel wall …

Our understanding of endocytosis has evolved remarkably in little more than a decade. This
is the result not only of advances in our knowledge of its molecular and biological workings …

Introduction A major challenge in treating central nervous system (CNS) disorders is to
achieve adequate drug delivery across the blood–brain barrier (BBB). Receptor-mediated …

Endothelial hyperpermeability is a significant problem in vascular inflammation associated
with trauma, ischaemia–reperfusion injury, sepsis, adult respiratory distress syndrome …

Lipid rafts are plasma membrane microdomains enriched in cholesterol and sphingolipids
that are involved in the lateral compartmentalization of molecules at the cell surface …

Cell-associated proteoglycans provide highly complex and sophisticated systems to control
interactions of extracellular cell matrix components and soluble ligands with the cell surface …

Caveolae are plasma membrane invaginations prominent in all endothelial cells lining
blood vessels. Caveolae characteristically bud to form free cytoplasmic vesicles capable of …