Hypoxia-inducible factors (HIFs) are transcriptional activators that function as master
regulators of oxygen homeostasis, which is disrupted in disorders affecting the circulatory …

Hypoxia-inducible factors (HIFs) are broadly expressed in human cancers, and HIF1α and
HIF2α were previously suspected to promote tumour progression through largely …

Adaptation of cancer cells to their microenvironment is an important driving force in the
clonal selection that leads to invasive and metastatic disease. O 2 concentrations are …

Hypoxia-inducible factors (HIFs) are essential mediators of the cellular oxygen-signaling
pathway. They are heterodimeric transcription factors consisting of an oxygen-sensitive …

The induction of hypoxia-inducible factor 1 (HIF-1) activity, either as a result of intratumoral
hypoxia or loss-of-function mutations in the VHL gene, leads to a dramatic reprogramming of …

Hypoxia is an imbalance between oxygen supply and demand that occurs in cancer and in
ischemic cardiovascular disease. Hypoxia-inducible factor 1 (HIF-1) was originally identified …

Hypoxia (low O 2) is an essential microenvironmental driver of phenotypic diversity in
human solid cancers. Hypoxic cancer cells hijack evolutionarily conserved, O 2-sensitive …

Hypoxia-inducible factor 1 (HIF-1) regulates the transcription of many genes involved in key
aspects of cancer biology, including immortalization, maintenance of stem cell pools, cellular …

The acquired ability to induce the formation of a functional vasculature is a hallmark of
cancer. Blood vessels in tumors are formed through various mechanisms, among the most …

Hypoxia in solid tumors is an important predictor of treatment resistance and poor clinical
outcome. The significance of hypoxia in the development of resistance to radiotherapy has …