Brain-derived neurotrophic factor (BDNF) is one of the most widely distributed and
extensively studied neurotrophins in the mammalian brain. Among its prominent functions …

Major depressive disorder (MDD) is a debilitating illness characterized by neuroanatomical
and functional alterations in limbic structures, notably the prefrontal cortex (PFC), that can be …

How do antidepressants elicit an antidepressant response? Here, we review accumulating
evidence that the neurotrophin brain-derived neurotrophic factor (BDNF) serves as a …

Brain-derived neurotrophic factor (BDNF)—a member of a small family of secreted proteins
that includes nerve growth factor, neurotrophin 3 and neurotrophin 4—has emerged as a …

Increasing evidence points to an association between major depressive disorders (MDDs)
and diverse types of GABAergic deficits. In this review, we summarize clinical and preclinical …

Nerve growth factor (NGF) was discovered in the early 1950s due to its trophic (survival-and
growth-promoting) effects on sensory and sympathetic neurons (Levi-Montalcini and …

Astrocytes are highly specialized glial cells responsible for trophic and metabolic support of
neurons. They are associated to ionic homeostasis, the regulation of cerebral blood flow and …

Develo** networks follow common rules to shift from silent cells to coactive networks that
operate via thousands of synapses. This review deals with some of these rules and in …

Long-term potentiation and long-term depression are processes that have been widely
studied to understand the molecular basis of information storage in the brain. Glutamate …

Proper developmental, neural cell-type-specific, and activity-dependent regulation of
GABAergic transmission is essential for virtually all aspects of CNS function. The number of …