Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

L Galluzzi, I Vitale, SA Aaronson, JM Abrams… - Cell Death & …, 2018‏ - nature.com
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

Lysosomal membrane permeabilization and cell death

F Wang, R Gómez‐Sintes, P Boya - Traffic, 2018‏ - Wiley Online Library
Lysosomes are membrane‐enclosed organelles that mediate the intracellular degradation
of macromolecules. They play an essential role in calcium regulation and have emerged as …

Of the many cellular responses activated by TP53, which ones are critical for tumour suppression?

AF Thomas, GL Kelly, A Strasser - Cell Death & Differentiation, 2022‏ - nature.com
The tumour suppressor TP53 is a master regulator of several cellular processes that
collectively suppress tumorigenesis. The TP53 gene is mutated in~ 50% of human cancers …

Self-consumption: the interplay of autophagy and apoptosis

G Marino, M Niso-Santano, EH Baehrecke… - … reviews Molecular cell …, 2014‏ - nature.com
Autophagy and apoptosis control the turnover of organelles and proteins within cells, and of
cells within organisms, respectively, and many stress pathways sequentially elicit …

Lysosomal membrane permeabilization in cell death: new evidence and implications for health and disease

A Serrano‐Puebla, P Boya - Annals of the New York academy …, 2016‏ - Wiley Online Library
Recent studies have demonstrated that, in addition to their central role in cellular catabolic
reactions, lysosomes are implicated in many cellular processes, including metabolism …

Lysosomal cell death mechanisms in aging

R Gómez-Sintes, MD Ledesma, P Boya - Ageing research reviews, 2016‏ - Elsevier
Lysosomes are degradative organelles essential for cell homeostasis that regulate a variety
of processes, from calcium signaling and nutrient responses to autophagic degradation of …

The DNA damage-regulated autophagy modulator DRAM1 links mycobacterial recognition via TLR-MYD88 to autophagic defense

M van der Vaart, CJ Korbee, GEM Lamers… - Cell host & …, 2014‏ - cell.com
Autophagy is an important defense mechanism against mycobacteria, the causative agents
of tuberculosis. The molecular mechanisms that link mycobacterial recognition to autophagy …

The transcription factors TFE3 and TFEB amplify p53 dependent transcriptional programs in response to DNA damage

OA Brady, E Jeong, JA Martina, M Pirooznia, I Tunc… - Elife, 2018‏ - elifesciences.org
The transcription factors TFE3 and TFEB cooperate to regulate autophagy induction and
lysosome biogenesis in response to starvation. Here we demonstrate that DNA damage …

Lysosomal proteins in cell death and autophagy

M Mrschtik, KM Ryan - The FEBS journal, 2015‏ - Wiley Online Library
Nearly 60 years ago, lysosomes were first described in the laboratory of Christian de Duve,
a discovery that significantly contributed to him being awarded a share of the 1974 Nobel …

Intersections between regulated cell death and autophagy

F Napoletano, O Baron, P Vandenabeele… - Trends in Cell …, 2019‏ - cell.com
In multicellular organisms, cell death is an essential aspect of life. Over the past decade, the
spectrum of different forms of regulated cell death (RCD) has expanded dramatically with …