This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Blood vessels are subjected to mechanical loads of pressure and flow, inducing smooth
muscle circumferential and endothelial shear stresses. The perception and response of …

Arterioles in the peripheral microcirculation regulate blood flow to and within tissues and
organs, control capillary blood pressure and microvascular fluid exchange, govern …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes coronavirus
disease (COVID-19) is one of the most serious global health crises in recent history. COVID …

Serum response factor (SRF) controls gene transcription in vascular smooth muscle cells
(VSMCs) and regulates VSMC phenotypic switch from a contractile to a synthetic state …

Polycystic kidney disease (PKD) is the most common genetic form of chronic kidney disease
(CKD), and it involves the development of multiple kidney cysts. Not enough medical …

The pathological involvement of anion channels in vascular dysfunction that occurs during
type 2 diabetes (T2D) is unclear. Here, we tested the hypothesis that TMEM16A, a calcium …

The antidiabetic drug empagliflozin is reported to produce a range of cardiovascular effects,
including a reduction in systemic blood pressure. However, whether empagliflozin directly …

PKD2 was first identified as the pathogenic protein for autosomal dominant polycystic kidney
disease (ADPKD) and is widely recognized as an ion channel. Subsequent studies have …

Abstract Polycystin-2 (TRPP2, PKD2, PC2) is the product of the PKD2 gene, whose
mutations cause Autosomal Dominant Polycystic Kidney Disease (ADPKD). PC2 belongs to …