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Role of extracellular matrix in development and cancer progression
The immense diversity of extracellular matrix (ECM) proteins confers distinct biochemical
and biophysical properties that influence cell phenotype. The ECM is highly dynamic as it is …
and biophysical properties that influence cell phenotype. The ECM is highly dynamic as it is …
Discovering cell-adhesion peptides in tissue engineering: beyond RGD
As an alternative to natural extracellular matrix (ECM) macromolecules, cell-adhesion
peptides (CAPs) have had tremendous impact on the design of cell culture platforms …
peptides (CAPs) have had tremendous impact on the design of cell culture platforms …
Fully synthetic matrices for in vitro culture of primary human intestinal enteroids and endometrial organoids
Epithelial organoids derived from human donor tissues are important tools in fields ranging
from regenerative medicine to drug discovery. Organoid culture requires expansion of …
from regenerative medicine to drug discovery. Organoid culture requires expansion of …
FAK controls the mechanical activation of YAP, a transcriptional regulator required for durotaxis
Focal adhesion kinase (FAK) is a key molecule in focal adhesions and regulates
fundamental processes in cells such as growth, survival, and migration. FAK is one of the …
fundamental processes in cells such as growth, survival, and migration. FAK is one of the …
Modulation of macrophages by in situ ligand bridging
Extracellular matrix (ECM) proteins containing cell‐attachable Arg‐Gly‐Asp (RGD)
sequences exhibit variable bridging and non‐bridging in fibronectin‐collagen and laminin …
sequences exhibit variable bridging and non‐bridging in fibronectin‐collagen and laminin …
Manipulating nanoparticle aggregates regulates receptor–ligand binding in macrophages
The receptor–ligand interactions in cells are dynamically regulated by modulation of the
ligand accessibility. In this study, we utilize size-tunable magnetic nanoparticle aggregates …
ligand accessibility. In this study, we utilize size-tunable magnetic nanoparticle aggregates …
Submolecular ligand size and spacing for cell adhesion
Cell adhesion occurs when integrin recognizes and binds to Arg–Gly–Asp (RGD) ligands
present in fibronectin. In this work, submolecular ligand size and spacing are tuned via …
present in fibronectin. In this work, submolecular ligand size and spacing are tuned via …
Substrate rigidity controls activation and durotaxis in pancreatic stellate cells
Abstract Pancreatic Ductal Adenocarcinoma (PDAC) is an aggressive malignancy
characterised by the presence of extensive desmoplasia, thought to be responsible for the …
characterised by the presence of extensive desmoplasia, thought to be responsible for the …
Magnetically tuning tether mobility of integrin ligand regulates adhesion, spreading, and differentiation of stem cells
Cells sense and respond to the surrounding microenvironment through binding of
membranous integrin to ligands such as the Arg-Gly-Asp (RGD) peptide. Previous studies …
membranous integrin to ligands such as the Arg-Gly-Asp (RGD) peptide. Previous studies …
Ligand coupling and decoupling modulates stem cell fate
In natural microenvironment, various proteins containing adhesive ligands in fibrous and
non‐fibrous structures dynamically couple and decouple to regulate stem cell fate. Herein …
non‐fibrous structures dynamically couple and decouple to regulate stem cell fate. Herein …