Tumor hypoxia resulting from abnormal and dysfunctional tumor vascular network poses a
substantial obstacle to immunotherapy. In fact, hypoxia creates an immunosuppressive …

Epithelial tissue homeostasis is closely associated with the self-renewal and differentiation
behaviors of epithelial stem cells (ESCs). p63, a well-known marker of ESCs, is an …

ADP-ribose is a versatile modification that plays a critical role in diverse cellular processes.
The addition of this modification is catalyzed by ADP-ribosyltransferases, among which …

Background & Aims Although small patient subsets benefit from current targeted strategies
or immunotherapy, gemcitabine remains the first-line drug for pancreatic cancer (PC) …

Besides the canonical function in ribosome biogenesis, there have been significant recent
advances towards the fascinating roles of the nucleolus in stress response, cell destiny …

The dysregulation of ribosome biogenesis is a hallmark of cancer, facilitating the adaptation
to altered translational demands essential for various aspects of tumor progression. This …

The coordinated integration of ribosomal RNA and protein into two functional ribosomal
subunits is safeguarded by quality control checkpoints that ensure ribosomes are correctly …

Ribosome biogenesis in the nucleolus is an important process that consumes 80% of a cell's
intracellular energy supply. Disruption of this process results in nucleolar stress, triggering …

Natural ageing of organisms and corresponding age-related diseases result mainly from
stem cell ageing and “inflammaging”. Mesenchymal stem cells (MSCs) exhibit very high …

Abstract p53 is a redox-sensitive transcription factor that can regulate multiple cell death
programs through different signaling pathways. In this review, we assess the role of p53 in …