Vortioxetine, a novel antidepressant for the treatment of major depressive disorder (MDD), is
a 5-HT 3, 5-HT 7 and 5-HT 1D receptor antagonist, 5-HT 1B receptor partial agonist, 5-HT …

The neurotransmitter transporters (NTTs) belonging to the solute carrier 6 (SLC6) gene
family (also referred to as the neurotransmitter-sodium-symporter family or Na+/Cl …

Recent advances in noninvasive imaging modalities have opened endless opportunities for
molecular diagnostic and therapeutic procedures. The term “molecular imaging” is broadly …

The authors developed and applied two new linearized reference tissue models for
parametric images of binding potential (BP) and relative delivery (R 1) for [11C] DASB …

OBJECTIVE: Minimum therapeutic doses of paroxetine and citalopram produce 80%
occupancy for the serotonin (5-HT) transporter (5-HTT). The authors used [11C] DASB …

Disabling fatigue is a symptom in a number of neurological diseases, including multiple
sclerosis, stroke and Parkinson's disease. We used 18F-dopa and 11C-DASB [N, N-dimethyl …

The highly evolutionarily conserved serotonin transporter (SERT) regulates the entire
serotoninergic system and its receptors via mod-ulation of extracellular fluid serotonin …

Context It is a common experience in temperate zones that individuals feel happier and
more energetic on bright and sunny days and many experience a decline in mood and …

This paper focuses on serotonin transporter 5-HTT imaging to investigate major depressive
disorder (MDD) and antidepressant occupancy. Such investigations have only recently been …

The highly diverse serotonergic system with at least 16 different receptor subtypes is
implicated in the pathophysiology of most neuropsychiatric disorders including affective and …