Chronic kidney disease (CKD) is a global health problem with rising incidence and
prevalence. Among several pathogenetic mechanisms responsible for disease progression …

Dyslipidaemia is a hallmark of chronic kidney disease (CKD). The severity of dyslipidaemia
not only correlates with CKD stage but is also associated with CKD-associated …

Podocytes are the key target cells for injury across the spectrum of primary and secondary
proteinuric kidney disorders, which account for up to 90% of cases of kidney failure …

Abstract Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are anti-hyperglycemic agents
that prevent glucose reabsorption in proximal tubular cells. SGLT2i improves renal …

Chronic kidney disease (CKD), defined as persistent (> 3 months) kidney functional loss,
has a growing prevalence (> 10% worldwide population) and limited treatment options …

Lipotoxicity is the dysregulation of the lipid environment and/or intracellular composition that
leads to accumulation of harmful lipids and ultimately to organelle dysfunction, abnormal …

Lipid dysmetabolism is one of the main features of diabetes mellitus and manifests by
dyslipidemia as well as the ectopic accumulation of lipids in various tissues and organs …

Alport syndrome (AS) is a hereditary kidney disease associated with proteinuria, hematuria
and progressive kidney failure. It is characterized by a defective glomerular basement …

Impaired cellular cholesterol efflux is a key factor in the progression of renal, cardiovascular,
and autoimmune diseases. Here we describe a class of 5-arylnicotinamide compounds …

Autophagy is a protective mechanism through which cells degrade and recycle proteins and
organelles to maintain cellular homeostasis and integrity. An accumulating body of evidence …