Cancer cell death is the utmost aim in cancer therapy. Anti-cancer agents can induce
apoptosis, mitotic catastrophe, senescence, or autophagy through the production of free …

Compared to conventional photon-based external beam radiation (PhXRT), carbon ion
radiotherapy (CIRT) has superior dose distribution, higher linear energy transfer (LET), and …

Clinical translation of cell‐based products is hampered by their limited predictive in vivo
performance. To overcome this hurdle, engineering strategies advocate to fabricate tissue …

The concomitant administration of ionising radiation (IR) in the form of external beam
radiotherapy or targeted radionuclide therapy (TRT) alongside radiosensitizing small …

Cisplatin, a widely used chemotherapeutic agent, has proven efficacy against various
malignancies. However, its clinical utility is hampered by its dose-limiting toxicities, including …

DNA double-strand breaks (DSBs) induced by ionising radiation are considered the major
cause of genotoxic mutations and cell death. While DSBs are dispersed throughout …

The number of patients treated with charged-particle radiotherapy as well as the number of
treatment centers is increasing worldwide, particularly regarding protons. However, high …

Background/Aim: This study aimed to establish a setup for ultra-high-dose-rate (FLASH)
carbon-ion irradiation, and to conduct the first human cell experiments using FLASH carbon …

Simple Summary Carbon-ion radiotherapy (CIRT) is a potentially curative treatment for
unresectable pelvic sarcomas/chordomas. Tumor control remains suboptimal in large pelvic …

Charged particle radiotherapy, mainly using protons and carbon ions, provides physical
characteristics allowing for a volume conformal irradiation and a reduction of the integral …