Mechanisms controlling cellular and systemic iron homeostasis

B Galy, M Conrad, M Muckenthaler - Nature Reviews Molecular Cell …, 2024 - nature.com
In mammals, hundreds of proteins use iron in a multitude of cellular functions, including vital
processes such as mitochondrial respiration, gene regulation and DNA synthesis or repair …

Targeting ferroptosis opens new avenues for the development of novel therapeutics

S Sun, J Shen, J Jiang, F Wang, J Min - Signal transduction and …, 2023 - nature.com
Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics,
including altered iron homeostasis, reduced defense against oxidative stress, and abnormal …

Molecular mechanisms of iron and heme metabolism

S Dutt, I Hamza, TB Bartnikas - Annual review of nutrition, 2022 - annualreviews.org
An abundant metal in the human body, iron is essential for key biological pathways
including oxygen transport, DNA metabolism, and mitochondrial function. Most iron is bound …

[HTML][HTML] Ferroptosis in health and disease

C Berndt, H Alborzinia, VS Amen, S Ayton, U Barayeu… - Redox biology, 2024 - Elsevier
Ferroptosis is a pervasive non-apoptotic form of cell death highly relevant in various
degenerative diseases and malignancies. The hallmark of ferroptosis is uncontrolled and …

Iron deficiency

SR Pasricha, J Tye-Din, MU Muckenthaler… - The Lancet, 2021 - thelancet.com
Iron deficiency is one of the leading contributors to the global burden of disease, and
particularly affects children, premenopausal women, and people in low-income and middle …

Ferroptosis: machinery and regulation

X Chen, J Li, R Kang, DJ Klionsky, D Tang - Autophagy, 2021 - Taylor & Francis
Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death caused by lipid
peroxidation, which is controlled by integrated oxidation and antioxidant systems. The iron …

Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects

Q Ru, Y Li, L Chen, Y Wu, J Min, F Wang - Signal transduction and …, 2024 - nature.com
Iron, an essential mineral in the body, is involved in numerous physiological processes,
making the maintenance of iron homeostasis crucial for overall health. Both iron overload …

Fighting age-related orthopedic diseases: focusing on ferroptosis

Q Ru, Y Li, W **e, Y Ding, L Chen, G Xu, Y Wu… - Bone research, 2023 - nature.com
Ferroptosis, a unique type of cell death, is characterized by iron-dependent accumulation
and lipid peroxidation. It is closely related to multiple biological processes, including iron …

On iron metabolism and its regulation

ACS Vogt, T Arsiwala, M Mohsen, M Vogel… - International journal of …, 2021 - mdpi.com
Iron is a critical metal for several vital biological processes. Most of the body's iron is bound
to hemoglobin in erythrocytes. Iron from senescent red blood cells is recycled by …

Gut microbiota bridges dietary nutrients and host immunity

L Fan, Y **a, Y Wang, D Han, Y Liu, J Li, J Fu… - Science China Life …, 2023 - Springer
Dietary nutrients and the gut microbiota are increasingly recognized to cross-regulate and
entrain each other, and thus affect host health and immune-mediated diseases. Here, we …