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Mechanisms controlling cellular and systemic iron homeostasis
In mammals, hundreds of proteins use iron in a multitude of cellular functions, including vital
processes such as mitochondrial respiration, gene regulation and DNA synthesis or repair …
processes such as mitochondrial respiration, gene regulation and DNA synthesis or repair …
Targeting ferroptosis opens new avenues for the development of novel therapeutics
S Sun, J Shen, J Jiang, F Wang, J Min - Signal transduction and …, 2023 - nature.com
Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics,
including altered iron homeostasis, reduced defense against oxidative stress, and abnormal …
including altered iron homeostasis, reduced defense against oxidative stress, and abnormal …
Molecular mechanisms of iron and heme metabolism
An abundant metal in the human body, iron is essential for key biological pathways
including oxygen transport, DNA metabolism, and mitochondrial function. Most iron is bound …
including oxygen transport, DNA metabolism, and mitochondrial function. Most iron is bound …
[HTML][HTML] Ferroptosis in health and disease
Ferroptosis is a pervasive non-apoptotic form of cell death highly relevant in various
degenerative diseases and malignancies. The hallmark of ferroptosis is uncontrolled and …
degenerative diseases and malignancies. The hallmark of ferroptosis is uncontrolled and …
Iron deficiency
Iron deficiency is one of the leading contributors to the global burden of disease, and
particularly affects children, premenopausal women, and people in low-income and middle …
particularly affects children, premenopausal women, and people in low-income and middle …
Ferroptosis: machinery and regulation
Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death caused by lipid
peroxidation, which is controlled by integrated oxidation and antioxidant systems. The iron …
peroxidation, which is controlled by integrated oxidation and antioxidant systems. The iron …
Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects
Iron, an essential mineral in the body, is involved in numerous physiological processes,
making the maintenance of iron homeostasis crucial for overall health. Both iron overload …
making the maintenance of iron homeostasis crucial for overall health. Both iron overload …
Fighting age-related orthopedic diseases: focusing on ferroptosis
Q Ru, Y Li, W **e, Y Ding, L Chen, G Xu, Y Wu… - Bone research, 2023 - nature.com
Ferroptosis, a unique type of cell death, is characterized by iron-dependent accumulation
and lipid peroxidation. It is closely related to multiple biological processes, including iron …
and lipid peroxidation. It is closely related to multiple biological processes, including iron …
On iron metabolism and its regulation
ACS Vogt, T Arsiwala, M Mohsen, M Vogel… - International journal of …, 2021 - mdpi.com
Iron is a critical metal for several vital biological processes. Most of the body's iron is bound
to hemoglobin in erythrocytes. Iron from senescent red blood cells is recycled by …
to hemoglobin in erythrocytes. Iron from senescent red blood cells is recycled by …
Gut microbiota bridges dietary nutrients and host immunity
L Fan, Y **a, Y Wang, D Han, Y Liu, J Li, J Fu… - Science China Life …, 2023 - Springer
Dietary nutrients and the gut microbiota are increasingly recognized to cross-regulate and
entrain each other, and thus affect host health and immune-mediated diseases. Here, we …
entrain each other, and thus affect host health and immune-mediated diseases. Here, we …