A general review of major global coagulation assays: thrombelastography, thrombin generation test and clot waveform analysis
MD Lancé - Thrombosis journal, 2015 - Springer
Thrombosis and hemorrhage are major contributors to morbidity and mortality. The
traditional laboratory tests do not supply enough information to diagnose and treat patients …
traditional laboratory tests do not supply enough information to diagnose and treat patients …
Thrombin generation testing in routine clinical practice: are we there yet?
Thrombin is the central enzyme in the coagulation cascade. Estimation of an individual's
potential to generate thrombin may correlate more closely with a hyper‐or hypo‐coagulable …
potential to generate thrombin may correlate more closely with a hyper‐or hypo‐coagulable …
An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia
A Sehgal, S Barros, L Ivanciu, B Cooley, J Qin… - Nature medicine, 2015 - nature.com
Hemophilia A and B are inherited bleeding disorders characterized by deficiencies in
procoagulant factor VIII (FVIII) or factor IX (FIX), respectively. There remains a substantial …
procoagulant factor VIII (FVIII) or factor IX (FIX), respectively. There remains a substantial …
[HTML][HTML] Severe hemophilia with mild bleeding phenotype: molecular characterization and global coagulation profile
E Santagostino, ME Mancuso, A Tripodi… - Journal of Thrombosis …, 2010 - Elsevier
Background: Patients with severe hemophilia may show very varied bleeding tendencies,
and the reasons for this heterogeneous clinical expression are unclear. The factor VIII/FIX …
and the reasons for this heterogeneous clinical expression are unclear. The factor VIII/FIX …
[HTML][HTML] Coagulation factors and the protein C system as determinants of thrombin generation in a normal population
Background: Thrombin generation is a powerful tool to probe overall plasma coagulability.
Objective: To determine which plasma factors influence the various parameters of the …
Objective: To determine which plasma factors influence the various parameters of the …
Thrombin generation: what have we learned?
Thrombin is a pivotal player in the coagulation system. In clotting blood a transient wave of
thrombin appears after a lag time. Clotting occurs at the start of the wave. The amount of …
thrombin appears after a lag time. Clotting occurs at the start of the wave. The amount of …
Thrombin generation and whole blood viscoelastic assays in the management of hemophilia: current state of art and future perspectives
G Young, B Sørensen, Y Dargaud… - Blood, The Journal …, 2013 - ashpublications.org
Hemophilia is a bleeding disorder that afflicts about 1 in 5000 males. Treatment relies upon
replacement of the deficient factor, and response to treatment both in clinical research and …
replacement of the deficient factor, and response to treatment both in clinical research and …
Evaluation of a standardized protocol for thrombin generation measurement using the calibrated automated thrombogram: an international multicentre study
The thrombin generation test (TGT) has demonstrated utility in evaluating overall hemostatic
capacity both in bleeding and thrombotic disorders. Although the test is currently well …
capacity both in bleeding and thrombotic disorders. Although the test is currently well …
Influence of coagulation factors and tissue factor concentration on the thrombin generation test in plasma
J Duchemin, B Pan-Petesch, B Arnaud… - Thrombosis and …, 2008 - thieme-connect.com
The thrombin generation test is used to study coagulation in patients with haemorrhagic
diseases or with high thrombotic risk. To our knowledge, this is the first study investigating …
diseases or with high thrombotic risk. To our knowledge, this is the first study investigating …
Targeting anticoagulant protein S to improve hemostasis in hemophilia
R Prince, L Bologna, M Manetti… - Blood, The Journal …, 2018 - ashpublications.org
Improved treatments are needed for hemophilia A and B, bleeding disorders affecting 400
000 people worldwide. We investigated whether targeting protein S could promote …
000 people worldwide. We investigated whether targeting protein S could promote …