Many types of human cells self-destruct to maintain biological homeostasis and defend the
body against pathogenic substances. This process, called regulated cell death (RCD), is …

Since their inception, rhodamine dyes have been extensively applied in biotechnology as
fluorescent markers or for the detection of biomolecules owing to their good optical physical …

Ferroptosis is evolving as a highly promising approach to combat difficult-to-treat tumour
entities including therapy-refractory and dedifferentiating cancers,–. Recently, ferroptosis …

Ferroptosis, a form of cell death driven by iron-dependent lipid peroxidation, was identified
as a distinct phenomenon and named a decade ago. Ferroptosis has been implicated in a …

Cell death is critical for the development and homeostasis of almost all multicellular
organisms. Moreover, its dysregulation leads to diverse disease states. Historically …

Enhancing the intracellular labile iron pool (LIP) represents a powerful, yet untapped
strategy for driving ferroptotic death of cancer cells. Here, we show that NRF2 maintains iron …

Ferroptosis is a non-apoptotic form of regulated cell death that is triggered by the
discoordination of regulatory redox mechanisms culminating in massive peroxidation of …

As an essential micronutrient, copper is required for a wide range of physiological processes
in virtually all cell types. Because the accumulation of intracellular copper can induce …

Ferroptosis is an iron-dependent form of regulated cell death that is triggered by the toxic
build-up of lipid peroxides on cellular membranes. In recent years, ferroptosis has garnered …

The maintenance of iron homeostasis is essential for proper cardiac function. A growing
body of evidence suggests that iron imbalance is the common denominator in many …