Diagnostic tools to differentiate between community-acquired bacterial and viral meningitis
are essential to target the potentially lifesaving antibiotic treatment to those at greatest risk …

Introduction Sepsis is a heterogeneous syndrome often misdiagnosed. Point-of-care (POC)
diagnostic tests are commonly used to guide decision and include host biomarkers and …

Background Optimization of antimicrobial stewardship is key to tackling antimicrobial
resistance, which is exacerbated by overprescription of antibiotics in pediatric emergency …

Introduction: Procalcitonin and presepsin have been suggested to be able to discriminate
bacterial and viral infections, also in children. This sco** review aims to better explore the …

Introduction: Fever is among the most common reason for medical assessment and
antibiotic prescription in practice. The aim of this study was to evaluate positive and negative …

Children and adolescents with severe neurological impairment (SNI) require specialized
care due to their complex medical needs. In particular, these patients are often affected by …

Pneumonia stands as the primary cause of death among children under five, yet current
diagnosis methods often result in inadequate or unnecessary treatments. Our research …

I have read with interest the paper by Heather R Jackson and colleagues showing that a six-
protein signature can accurately distinguish between definite bacterial and definite viral …

Dr D Buonsenso1 raises an important question on whether our six-protein signature will
have sufficient clinical benefit in discriminating bacterial from viral infections, greater than …

Differentiating bacterial from viral infections in children is a common clinical challenge.
Novel host immune biomarkers have the potential to aid thediagnosis of infection aetiology …