Connexins are known for their ability to mediate cell-cell communication via gap junctions
and also form hemichannels that pass ions and molecules over the plasma membrane when …

Cardiac connexin-43 (Cx43) creates gap junction channels (GJCs) at intercellular contacts
and hemi-channels (HCs) at the peri-junctional plasma membrane and sarcolemmal …

Cardiac arrhythmias are a primary contributor to sudden cardiac death, a major unmet
medical need. Because right ventricular (RV) dysfunction increases the risk for sudden …

Cx43, a major cardiac connexin, forms precursor hemichannels that accrue at the
intercalated disc to assemble as gap junctions. While gap junctions are crucial for electrical …

BACKGROUND: Kawasaki disease (KD) is an acute febrile illness and systemic vasculitis
often associated with cardiac sequelae, including arrhythmias. Abundant evidence indicates …

Duchenne muscular dystrophy (DMD) cardiomyopathy (DCM) is characterized by a
hypokinetic, dilated phenotype progressively increasing with age. Regular cardiac care is …

Background Alcohol, a widely abused drug, significantly diminishes life quality, causing
chronic diseases and psychiatric issues, with severe health, societal, and economic …

Increased oxidative stress contributes to cataract formation during aging. Anterior epithelial
cells are a frontline antioxidant defense system with powerful capacities to maintain redox …

The intercalated disc (ID) is a highly specialized structure that connects cardiomyocytes via
mechanical and electrical junctions. Although described in some detail by light microscopy …

A well-balanced intercellular communication between the different cells within the heart is
vital for the maintenance of cardiac homeostasis and function. Despite remarkable advances …