Aging is the greatest risk factor for a multitude of diseases including cardiovascular disease,
neurodegeneration and cancer. Despite decades of research dedicated to understanding …

The tripeptide glutathione (GSH), namely γ-L-glutamyl-L-cysteinyl-glycine, is an ubiquitous
low-molecular weight thiol nucleophile and reductant of utmost importance, representing the …

Aging is a complex phenomenon and its impact is becoming more relevant due to the rising
life expectancy and because aging itself is the basis for the development of age-related …

Redox biology is at the core of life sciences, accompanied by the close correlation of redox
processes with biological activities. Redox homeostasis is a prerequisite for human health …

It has been 60 yr since the discovery of reactive oxygen species (ROS) in biology and the
beginning of the scientific community's attempt to understand the impact of the unpaired …

Mitochondria and lysosomes are functionally linked, and their interdependent decline is a
hallmark of aging and disease. Despite the long-standing connection between these …

Unfolded stress response (UPR) is a conserved cellular pathway involved in protein quality
control to maintain homeostasis under different conditions and disease states characterized …

Some of the most challenging stress conditions that organisms encounter during their
lifetime involve the transient accumulation of reactive oxygen and chlorine species …

Oxidation and alkylation of nucleobases are known to disrupt their base-pairing properties
within RNA. It is, however, unclear whether organisms have evolved general mechanism (s) …

Significance: Once considered to be mere by-products of metabolism, reactive oxygen,
nitrogen and sulfur species are now recognized to play important roles in diverse cellular …