[HTML][HTML] APOBEC3-Related Editing and Non-Editing Determinants of HIV-1 and HTLV-1 Restriction

S Leong, H Nasser, T Ikeda - International Journal of Molecular Sciences, 2025 - mdpi.com
The apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3 (APOBEC3/A3)
family of cytosine deaminases serves as a key innate immune barrier against invading …

Stably expressed APOBEC3H forms a barrier for cross-species transmission of simian immunodeficiency virus of chimpanzee to humans

Z Zhang, Q Gu, M de Manuel Montero, IG Bravo… - PLoS …, 2017 - journals.plos.org
APOBEC3s (A3s) are potent restriction factors of human immunodeficiency virus type
1/simian immunodeficiency viruses (HIV-1/SIV), and can repress cross-species …

Natural APOBEC3C variants can elicit differential HIV-1 restriction activity

BD Anderson, T Ikeda, SA Moghadasi, AS Martin… - Retrovirology, 2018 - Springer
Abstract Background The APOBEC3 (A3) family of DNA cytosine deaminases provides an
innate barrier to infection by retroviruses including HIV-1. A total of five enzymes, A3C, A3D …

Feline APOBEC3s, barriers to cross-species transmission of FIV?

Z Zhang, Q Gu, D Marino, KL Lee, IK Kong… - Viruses, 2018 - mdpi.com
The replication of lentiviruses highly depends on host cellular factors, which defines their
species-specific tropism. Cellular restriction factors that can inhibit lentiviral replication were …

Multifaceted HIV‐1 Vif interactions with human E3 ubiquitin ligase and APOBEC3s

Y Hu, KM Knecht, Q Shen, Y **ong - The FEBS journal, 2021 - Wiley Online Library
APOBEC3 (A3) proteins are a family of host antiviral restriction factors that potently inhibit
various retroviral infections, including human immunodeficiency virus (HIV)‐1. To overcome …

Loop 1 of APOBEC3C regulates its antiviral activity against HIV-1

AAJ Vasudevan, K Balakrishnan, CGW Gertzen… - Journal of molecular …, 2020 - Elsevier
Abstract APOBEC3 deaminases (A3s) provide mammals with an anti-retroviral barrier by
catalyzing dC-to-dU deamination on viral ssDNA. Within primates, A3s have undergone a …

Enhancing the catalytic deamination activity of APOBEC3C is insufficient to inhibit Vif-deficient HIV-1

AAJ Vasudevan, H Hofmann, D Willbold… - Journal of molecular …, 2017 - Elsevier
The retroviral restriction factors of the APOBEC3 (A3) cytidine deaminase family catalyze the
deamination of cytidines in single-stranded viral DNA. APOBEC3C (A3C) is a strong antiviral …

Selection Pressure Regulates the Evolution-Structure–Function Paradigm of Monocyte Chemoattractant Protein Family

N Nagar, K Gulati, KM Poluri - Journal of Molecular Evolution, 2025 - Springer
Monocyte chemoattractant proteins (MCPs) are involved in monocyte trafficking during
severe inflammation by modulating the chemokine-glycosaminoglycan-receptor signaling …

Molecular and geographic characterization of HIV-1 BF recombinant viruses

JSM Souza, JJS Júnior, C Brites, JP Monteiro-Cunha - Virus Research, 2019 - Elsevier
Abstract The Human Immunodeficiency Virus Type 1 (HIV-1) presents a wide genetic
variability, which is represented by four groups, nine subtypes of group M and several …

Identification of a conserved interface of human immunodeficiency virus type 1 and feline immunodeficiency virus Vifs with Cullin 5

Q Gu, Z Zhang, CGW Gertzen, D Häussinger… - Journal of …, 2018 - journals.asm.org
Members of the apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like
(APOBEC3 [A3]) family of DNA cytidine deaminases are intrinsic restriction factors against …