Encapsulation and assessment of therapeutic cargo in engineered exosomes: a systematic review

Z Chen, M **ong, J Tian, D Song, S Duan… - Journal of …, 2024 - Springer
Exosomes are nanoscale extracellular vesicles secreted by cells and enclosed by a lipid
bilayer membrane containing various biologically active cargoes such as proteins, lipids …

A comprehensive review of engineered exosomes from preparation strategy to therapy applications

X Fan, Y Zhang, W Liu, M Shao, Y Gong, T Wang… - Biomaterials …, 2024 - pubs.rsc.org
Exosomes exhibit high bioavailability, biological stability, targeted specificity, low toxicity,
and low immunogenicity in shuttling various bioactive molecules such as proteins, lipids …

Genetically engineered loaded extracellular vesicles for drug delivery

Z Erana-Perez, M Igartua, E Santos-Vizcaino… - Trends in …, 2024 - cell.com
The use of extracellular vesicles (EVs) for drug delivery is being widely explored by
scientists from several research fields. To fully exploit their therapeutic potential, multiple …

Advances in Extracellular-Vesicles-Based Diagnostic and Therapeutic Approaches for Ocular Diseases

Y Su, M Chen, W Xu, P Gu, X Fan - ACS nano, 2024 - ACS Publications
Extracellular vesicles (EVs) are nanoscale membrane vesicles of various sizes that can be
secreted by most cells. EVs contain a diverse array of cargo, including RNAs, lipids …

Enhanced therapeutic efficacy against melanoma through exosomal delivery of hesperidin

DN Kumar, A Chaudhuri, D Dehari… - Molecular …, 2024 - ACS Publications
Melanoma, characterized as the most aggressive and metastatic form of skin cancer,
currently has limited treatment options, predominantly chemotherapy and radiation therapy …

Exosomes for neurodegenerative diseases: diagnosis and targeted therapy

H Tao, B Gao - Journal of Neurology, 2024 - Springer
Abstract Purpose of Review Neurodegenerative diseases are still challenging clinical
issues, with no curative interventions available and early, accurate diagnosis remaining …

[HTML][HTML] Fluorescence tracking of small extracellular vesicles in vivo

Y Chen, Y Shi, Z Tao - Pharmaceutics, 2023 - mdpi.com
In this study, we employed organic and inorganic dyes that have fluorescence under visible
or near-infrared light region to stain human umbilical cord (Huc) mesenchymal stem cell …

Functionalized solid lipid nanoparticles combining docetaxel and erlotinib synergize the anticancer efficacy against triple-negative breast cancer

A Chaudhuri, DN Kumar, D Kumar… - European Journal of …, 2024 - Elsevier
The goal of the study was to fabricate folic acid functionalized docetaxel (DOC)/erlotinib
(ERL)-loaded solid lipid nanoparticles (SLNs) to synergistically increase the anticancer …

[HTML][HTML] Combinatorial delivery of docetaxel-and erlotinib-loaded functionalized nanostructured lipid carriers for the treatment of triple-negative breast cancer using …

A Chaudhuri, DN Kumar, SK Srivastava, D Kumar… - Pharmaceutics, 2024 - mdpi.com
This study explored the combined administration of docetaxel (DOC) and erlotinib (ERL)
using nanostructured lipid carriers (NLCs), with folic acid (FA) conjugation to enhance their …

Application of exosomes as nanocarriers in cancer therapy

J Hu, J Zhu, J Chai, Y Zhao, J Luan… - Journal of Materials …, 2023 - pubs.rsc.org
Cancer remains the most common lethal disease in the world. Although the treatment
choices for cancer are still limited, significant progress has been made over the past few …