Antimicrobial resistance in ESKAPE pathogens

DMP De Oliveira, BM Forde, TJ Kidd… - Clinical microbiology …, 2020 - Am Soc Microbiol
Antimicrobial-resistant ESKAPE (E nterococcus faecium, S taphylococcus aureus, K
lebsiella pneumoniae, A cinetobacter baumannii, P seudomonas aeruginosa, and E …

Population genomics of Klebsiella pneumoniae

KL Wyres, MMC Lam, KE Holt - Nature Reviews Microbiology, 2020 - nature.com
Klebsiella pneumoniae is a common cause of antimicrobial-resistant opportunistic infections
in hospitalized patients. The species is naturally resistant to penicillins, and members of the …

Emerging antimicrobial-resistant high-risk Klebsiella pneumoniae clones ST307 and ST147

G Peirano, L Chen, BN Kreiswirth… - Antimicrobial agents and …, 2020 - Am Soc Microbiol
There is an enormous global public health burden due to antimicrobial-resistant (AMR)
Klebsiella pneumoniae high-risk clones. K. pneumoniae ST307 and ST147 are recent …

Extended-spectrum β-lactamase-producing Enterobacteriaceae: update on molecular epidemiology and treatment options

G Peirano, JDD Pitout - Drugs, 2019 - Springer
Extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae are a major global
public health concern. Presently, Escherichia coli with CTX-Ms are the most common …

The global ascendency of OXA-48-type carbapenemases

JDD Pitout, G Peirano, MM Kock… - Clinical microbiology …, 2019 - Am Soc Microbiol
Surveillance studies have shown that OXA-48-like carbapenemases are the most common
carbapenemases in Enterobacterales in certain regions of the world and are being …

OXA-48-like β-lactamases: global epidemiology, treatment options, and development pipeline

SE Boyd, A Holmes, R Peck… - Antimicrobial agents …, 2022 - Am Soc Microbiol
Modern medicine is threatened by the rising tide of antimicrobial resistance, especially
among Gram-negative bacteria, where resistance to β-lactams is most often mediated by β …

[HTML][HTML] Genomic epidemiology of global carbapenemase-producing Escherichia coli, 2015–2017

G Peirano, L Chen, D Nobrega, TJ Finn… - Emerging Infectious …, 2022 - ncbi.nlm.nih.gov
We describe the global molecular epidemiology of 229 carbapenemase-producing
Escherichia coli in 36 countries during 2015–2017. Common carbapenemases were …

Antimicrobial resistance rates and surveillance in sub-Saharan Africa: where are we now?

S Kariuki, K Kering, C Wairimu, R Onsare… - Infection and drug …, 2022 - Taylor & Francis
Introduction Although antimicrobials have traditionally been used to treat infections and
improve health outcomes, resistance to commonly used antimicrobials has posed a major …

CRISPR-Cas9-Mediated Carbapenemase Gene and Plasmid Curing in Carbapenem-Resistant Enterobacteriaceae

M Hao, Y He, H Zhang, XP Liao, YH Liu… - Antimicrobial agents …, 2020 - Am Soc Microbiol
Combating plasmid-mediated carbapenem resistance is essential to control and prevent the
dissemination of carbapenem-resistant Enterobacteriaceae (CRE). Here, we conducted a …

ESKAPE pathogens: antimicrobial resistance, epidemiology, clinical impact and therapeutics

WR Miller, CA Arias - Nature Reviews Microbiology, 2024 - nature.com
The rise of antibiotic resistance and a dwindling antimicrobial pipeline have been
recognized as emerging threats to public health. The ESKAPE pathogens—Enterococcus …