Mechanisms underlying the protective effects of mesenchymal stem cell-based therapy

XL Fan, Y Zhang, X Li, QL Fu - Cellular and molecular life sciences, 2020 - Springer
Mesenchymal stem cells (MSCs) have been extensively investigated for the treatment of
various diseases. The therapeutic potential of MSCs is attributed to complex cellular and …

[HTML][HTML] Artificial intelligence in regenerative medicine: applications and implications

H Nosrati, M Nosrati - Biomimetics, 2023 - mdpi.com
The field of regenerative medicine is constantly advancing and aims to repair, regenerate, or
substitute impaired or unhealthy tissues and organs using cutting-edge approaches such as …

Mesenchymal stem cell‐based immunomodulation: properties and clinical application

M Wang, Q Yuan, L **e - Stem cells international, 2018 - Wiley Online Library
Mesenchymal stem cells (MSCs) are multipotent stem cells characterized by self‐renewal,
production of clonal cell populations, and multilineage differentiation. They exist in nearly all …

Interactions between mesenchymal stem cells and the immune system

N Li, J Hua - Cellular and molecular life sciences, 2017 - Springer
In addition to being multi-potent, mesenchymal stem cells (MSCs) possess
immunomodulatory functions that have been investigated as potential treatments in various …

Mesenchymal stem cell‐based therapy for kidney disease: a review of clinical evidence

AJ Peired, A Sisti, P Romagnani - Stem cells international, 2016 - Wiley Online Library
Mesenchymal stem cells form a population of self‐renewing, multipotent cells that can be
isolated from several tissues. Multiple preclinical studies have demonstrated that the …

Efficacy and safety of umbilical cord mesenchymal stem cell therapy for rheumatoid arthritis patients: a prospective phase I/II study

L Wang, S Huang, S Li, M Li, J Shi, W Bai… - Drug design …, 2019 - Taylor & Francis
Background The traditional anti-inflammation disease-modifying anti-rheumatic drugs
(DMARDs) have limited therapeutic effects in rheumatoid arthritis (RA) patients. We …

Placental mesenchymal stem cell-derived extracellular vesicles promote myelin regeneration in an animal model of multiple sclerosis

K Clark, S Zhang, S Barthe, P Kumar, C Pivetti… - Cells, 2019 - mdpi.com
Mesenchymal stem/stromal cells (MSCs) display potent immunomodulatory and
regenerative capabilities through the secretion of bioactive factors, such as proteins …

Human mesenchymal stem cells genetically engineered to overexpress brain-derived neurotrophic factor improve outcomes in Huntington's disease mouse models

K Pollock, H Dahlenburg, H Nelson, KD Fink, W Cary… - Molecular Therapy, 2016 - cell.com
Huntington's disease (HD) is a fatal degenerative autosomal dominant neuropsychiatric
disease that causes neuronal death and is characterized by progressive striatal and then …

Exosomal microRNAs derived from umbilical mesenchymal stem cells inhibit hepatitis C virus infection

X Qian, C Xu, S Fang, P Zhao, Y Wang… - Stem cells …, 2016 - academic.oup.com
Hepatitis C virus (HCV) is a significant global public health problem, causing more than
350,000 deaths every year. Although the development of direct-acting antivirals has …

Efficacy and Safety of Mesenchymal Stem Cell Transplantation in the Treatment of Autoimmune Diseases (Rheumatoid Arthritis, Systemic Lupus Erythematosus …

L Zeng, G Yu, K Yang, W **ang, J Li… - Stem cells …, 2022 - Wiley Online Library
Objective. To evaluate the efficacy and safety of mesenchymal stem cell (MSC)
transplantation in the treatment of autoimmune diseases. Methods. The Chinese and …