[HTML][HTML] Haemonchus contortus: the then and now, and where to from here?

DL Emery, PW Hunt, LF Le Jambre - International Journal for Parasitology, 2016 - Elsevier
Haemonchus contortus (Barber's pole worm or “BPW”) is the nematode “nemesis” of small
ruminant production systems in tropical and subtropical regions of the world. Its reputation …

Immunity to helminths: resistance, regulation, and susceptibility to gastrointestinal nematodes

RK Grencis - Annual review of immunology, 2015 - annualreviews.org
Helminth parasites are a highly successful group of pathogens that challenge the immune
system in a manner distinct from rapidly replicating infectious agents. Of this group …

Immunity against helminths: interactions with the host and the intercurrent infections

E Moreau, A Chauvin - BioMed Research International, 2010 - Wiley Online Library
Helminth parasites are of considerable medical and economic importance. Studies of the
immune response against helminths are of great interest in understanding interactions …

Advances in the Development of Anti-Haemonchus contortus Vaccines: Challenges, Opportunities, and Perspectives

M Ehsan, RS Hu, QL Liang, JL Hou, X Song, R Yan… - Vaccines, 2020 - mdpi.com
The gastrointestinal nematode parasite Haemonchus contortus (H. contortus) is a resident of
tropical and subtropical regions worldwide that imposes significant production losses …

Immune responses associated with resistance to haemonchosis in sheep

F Alba-Hurtado… - BioMed research …, 2013 - Wiley Online Library
This paper examines the known immunological and genetic factors associated with sheep
resistance to infection by Haemonchus contortus. Such resistance is an inheritable genetic …

Leucocyte-derived extracellular trap formation significantly contributes to Haemonchus contortus larval entrapment

T Muñoz-Caro, MC Rubio R, LMR Silva… - Parasites & vectors, 2015 - Springer
Background Polymorphonuclear neutrophil (PMN) and eosinophil extracellular trap (ETs)
formation has recently been described as an important host effector mechanism against …

Eosinophil interactions with Haemonchus contortus larvae in the ovine gastrointestinal tract

A Balic, CP Cunningham… - Parasite immunology, 2006 - Wiley Online Library
Sheep were immunized by weekly oral infections with Haemonchus contortus for 9 weeks
followed by anthelmintic treatment. They were challenged either 9 or 22 weeks later with …

Serine protease inhibitors of parasitic helminths

AJ Molehin, GN Gobert, DP McMANUS - Parasitology, 2012 - cambridge.org
Serine protease inhibitors (serpins) are a superfamily of structurally conserved proteins that
inhibit serine proteases and play key physiological roles in numerous biological systems …

Gastrointestinal nematode challenge induces some conserved gene expression changes in the gut mucosa of genetically resistant sheep

A Ingham, A Reverter, R Windon, P Hunt… - International journal for …, 2008 - Elsevier
Sheep have a varying ability to resist infection with gastrointestinal nematodes. This ability is
due in part to genetic differences that exist between individuals. In order to define these …

A Th2 type of immune response is associated with increased resistance to Haemonchus contortus in naturally infected Gulf Coast Native lambs

KP Shakya, JE Miller, DW Horohov - Veterinary Parasitology, 2009 - Elsevier
Haemonchus contortus is one of the major nematode parasites causing substantial
economic losses in small ruminant farming worldwide. Recently, effectiveness of …