The serotonergic pathways originating in the dorsal and median raphe nuclei (DR and MnR,
respectively) are critically involved in cortical function. Serotonin (5-HT), acting on …

The introduction of atypical antipsychotics (AAPs) since the discovery of its prototypical drug
clozapine has been a revolutionary pharmacological step for treating psychotic patients as …

To better characterize hippocampal pathophysiology in schizophrenia, we conducted a
longitudinal study evaluating hippocampal functional connectivity during resting state, using …

Aripiprazole was the first antipsychotic developed to possess agonist properties at
dopamine D2 autoreceptors, a groundbreaking strategy that presented a new vista for …

Abstract Background and Purpose Clozapine is an effective antipsychotic for treatment‐
resistant schizophrenia, but its discontinuation leads to discontinuation syndrome/catatonia …

Intravenous infusion of lanicemine (formerly AZD6765), a low trap** non-selective N-
methyl-D-aspartate (NMDA) receptor antagonist, induces antidepressant effects with a …

A variety of serotonin (5-HT) receptors, especially 5-HT 2A, 5-HT 1A, 5-HT 6, 5-HT 7, and 5-
HT 2C, have been postulated to contribute to the mechanism of action of atypical …

Background: Impairment in episodic memory is one of the most robust findings in
schizophrenia. Disruptions of fronto‐temporal functional connectivity that could explain …

Schizophrenia is a severe mental illness characterized by alterations in processes that
regulate both synaptic plasticity and functional connectivity between brain regions …

Safety concerns have been raised about clozapine-induced cardiotoxicity particularly in
young patients. The exact mechanism of clozapine cardiotoxicity has not yet been …