Mitochondrial permeability transition pore (mPTP) plays a central role in alterations of
mitochondrial structure and function leading to neuronal injury relevant to aging and …

Although Alzheimer's disease (AD) characterized with senile plaques and neurofibrillary
tangles has been found for over 100 years, its molecular mechanisms are ambiguous. More …

A series of novel scaffold of N-substituted pyrazole derived α-aminophosphonates were
designed, synthesized and evaluated for their anti-cholinesterase activity. Porcine …

In the current study, 14 new benzothiazole–piperazine compounds were designed to meet
the structural requirements of acetylcholine esterase (AChE) inhibitors. The target …

Abstract A number of N-(2-(1H-indol-3-yl) ethyl)-2-oxo-2H-chromene-3-carboxamides were
synthesized and tested against AChE and BuChE. The in vitro assessment of the …

Cyclophilin D (CypD) is a peptidyl prolyl isomerase F that resides in the mitochondrial matrix
and associates with the inner mitochondrial membrane during the mitochondrial membrane …

Fluorine-containing heterocycles continue to receive considerable attention due to their
unique properties. In medicinal chemistry, the incorporation of fluorine in small molecules …

Current possibilities of Alzheimer's disease (AD) treatment are very limited and are based on
administration of cholinesterase inhibitors (donepezil, rivastigmine, galantamine) and/or N …

Alzheimer's disease (AD) is the most common dementia. No cure exists, and current
treatment only manages early symptoms. Mitochondrial dysfunction is a hallmark of amyloid …

Background: Neurodegenerative diseases such as Alzheimer's disease (AD), amyotrophic
lateral sclerosis, Parkinson's disease (PD), spinal cerebellar ataxias, and spinal and bulbar …