The importance of time is ever prevalent in our world, and disruptions to the normal
light/dark and sleep/wake cycle have now become the norm rather than the exception for a …

Seasonality patterns are reported in various psychiatric disorders. The current paper
summarizes findings on brain adaptations associated with seasonal changes, factors that …

The Review summarizes much of particle physics and cosmology. Using data from previous
editions, plus 3,324 new measurements from 878 papers, we list, evaluate, and average …

Background During the COVID-19 pandemic, a structural reorganization was imposed on
public health systems. Psychiatry services were also affected with the imposed reduction of …

Major mood syndromes are among the most common and disabling mental disorders.
However, a lack of clear delineation of their underlying pathophysiological mechanisms is a …

The etiology and clinical course of bipolar disorder are considered to be determined by
genetic and environmental factors. Although the kindling hypothesis emphasizes the impact …

Aims To systematically review the literature on the efficacy and tolerability of the major
chronotherapeutic treatments of bipolar disorders (BD)—bright light therapy (LT), dark …

Background Virtually, all organisms on Earth have their own circadian rhythm, and humans
are no exception. Circadian rhythms are associated with various human states, especially …

Background: The use of light for its antidepressant action dates back to the beginnings of
civilization. Three decades ago, the use of bright-light therapy (BLT) for treating Seasonal …

Objectives The discovery of the blue lightsensitive retinal photoreceptor responsible for
signaling daytime to the brain suggested that light to the circadian system could be inhibited …