Transition-metal-catalyzed, coordination-assisted C (sp3)–H functionalization has
revolutionized synthetic planning over the past few decades as the use of these directing …

During the past decades, synthetic organic chemistry discovered that directing group
assisted C–H activation is a key tool for the expedient and siteselective construction of C–C …

Transition-metal catalyzed reactions that are able to construct complex aliphatic amines from
simple, readily available feedstocks have become a cornerstone of modern synthetic …

This Review summarizes the advancements in Pd-catalyzed C (sp3)–H activation via
various redox manifolds, including Pd (0)/Pd (II), Pd (II)/Pd (IV), and Pd (II)/Pd (0). While few …

Transition metal-catalyzed direct functionalization of C–H bonds is one of the key emerging
strategies that is currently attracting tremendous attention with the aim to provide alternative …

Conspectus In recent years, carbon–hydrogen bond functionalization has evolved from an
organometallic curiosity to a tool used in mainstream applications in the synthesis of …

Differentiating between two highly similar C–H bonds in a given molecule remains a
fundamental challenge in synthetic organic chemistry. Directing group assisted strategies for …

In recent years, the pharmaceutical market has experienced a paradigm shift; as small
molecules had long been thought of as the ultimate therapeutics, the use of biologics …

Methods that enable the practical and selective functionalization of traditionally unreactive
aliphatic C–H bonds have synthetic applications in fields ranging from drug discovery to …

The site‐selective functionalization of unactivated C (sp3)− H bonds remains one of the
greatest challenges in organic synthesis. Herein, we report on the site‐selective δ‐C (sp3) …