Stem cells (SCs) maintain tissue homeostasis and repair wounds. Despite marked variation
in tissue architecture and regenerative demands, SCs often follow similar paradigms in …

Biomaterial choice is an essential step during the development tissue engineering and
regenerative medicine (TERM) applications. The selected biomaterial must present …

Extracellular matrix (ECM) is a non-cellular three-dimensional macromolecular network
composed of collagens, proteoglycans/glycosaminoglycans, elastin, fibronectin, laminins …

While the majority of cells contain a single nucleus, cell types such as trophoblasts,
osteoclasts, and skeletal myofibers require multinucleation. One advantage of …

Cardiac and skeletal striated muscles are intricately designed machines responsible for
muscle contraction. Coordination of the basic contractile unit, the sarcomere, and the …

Muscular dystrophies are a heterogeneous group of inherited disorders that share similar
clinical features and dystrophic changes on muscle biopsy. An improved understanding of …

Muscular dystrophies are primary diseases of muscle due to mutations in more than 40
genes, which result in dystrophic changes on muscle biopsy. Now that most of the genes …

The X-linked muscle-wasting disease Duchenne muscular dystrophy is caused by mutations
in the gene encoding dystrophin. There is currently no effective treatment for the disease; …

Basement membranes are specialized extracellular matrices consisting of tissue-specific
organizations of multiple matrix molecules and serve as structural barriers as well as …

Laminins are a large family of conserved, multidomain trimeric basement membrane
proteins that contribute to the structure of extracellular matrix and influence the behavior of …