Juvenile and adult dermatomyositis (DM) have multiple commonalities, yet display differing
prevalence of features, outcomes and comorbidities. In general, compared with the disease …

Abstract Knowledge on idiopathic inflammatory myopathy (IIM) has evolved with the
identification of myositis-associated and myositis-specific antibodies, development of …

Objective: To evaluate the diagnostic value of myxovirus resistance A (MxA) expression in
the cytoplasm of myofibers in the diagnosis of dermatomyositis (DM). Methods: We assessed …

Different mechanisms have been proposed to explain the pathological basis of
perifascicular muscle fibre atrophy in dermatomyositis. These include ischaemia due to …

Dermatomyositis and polymyositis (DM/PM) are systemic autoimmune diseases
characterized by proximal muscle weakness. The underlying pathogenetic mechanism of …

Evidence about the relevance of the complement system, a highly conserved constituent of
the innate immunity response that orchestrates the elimination of pathogens and the …

Idiopathic inflammatory myopathies (IIM), collectively known as myositis, are a composite
group of rare autoimmune diseases affecting mostly skeletal muscle, although other organs …

Introduction The objective was to characterize the clinical and myopathologic features of
patients with scleroderma-polymyositis (SSc-PM) overlap compared with a population of …

Background The objective of the study was to explore the disease pathways activated in the
inflammatory foci of skin lesions in cutaneous lupus erythematosus (CLE) and …

Much work has been done to unveil the mechanisms behind the pathogenesis of
dermatomyositis (DM)–mainly those involving certain pathogenic cytokines, termed …