Summary Each year, an estimated 7· 7 million deaths are attributed to bacterial infections, of
which 4.95 million are associated with drug-resistant pathogens, and 1· 27 million are …

Before the coronavirus 2019 (COVID-19) pandemic began, antimicrobial resistance (AMR)
was among the top priorities for global public health. Already a complex challenge, AMR …

Carbapenem resistance in gram-negative bacteria has caused a global epidemic that
continues to grow. Although carbapenemase-producing Enterobacteriaceae have received …

Public health interventions to control the current epidemic of carbapenem-resistant
Klebsiella pneumoniae rely on a comprehensive understanding of its emergence and …

Background Infections due to antibiotic-resistant bacteria are threatening modern health
care. However, estimating their incidence, complications, and attributable mortality is …

New Delhi metallo-β-lactamase (NDM) is a metallo-β-lactamase able to hydrolyze almost all
β-lactams. Twenty-four NDM variants have been identified in> 60 species of 11 bacterial …

The antibacterial agents currently in clinical development are predominantly derivatives of
well-established antibiotic classes and were selected to address the class-specific …

This study aimed to investigate the dissemination and characteristics of bla KPC, bla NDM,
bla OXA-48-like, bla IMP, and bla VIM among the carbapenem-resistant Enterobacteriaceae …

Summary Background Hypervirulent Klebsiella pneumoniae strains often cause life-
threatening community-acquired infections in young and healthy hosts, but are usually …

The dramatic global rise of MDR and XDR Enterobacterales in human medicine forced
clinicians to the reintroduction of colistin as last-resort drug. Meanwhile, colistin is used in …