Intracerebral haemorrhage (ICH) is the most lethal subtype of stroke but currently lacks
effective treatment. Microglia are among the first non-neuronal cells on the scene during the …

Intracerebral haemorrhage accounts for about 10–15% of all strokes and is associated with
high mortality and morbidity. No successful phase 3 clinical trials for this disorder have been …

Brain edema is a potentially fatal pathological state that occurs after brain injuries such as
stroke and head trauma. In the edematous brain, excess accumulation of extracellular fluid …

Oxidative stress plays an important role in secondary brain injury (SBI) after intracerebral
hemorrhage (ICH), but the underling mechanism has not been fully elucidated. Recently, the …

Intracerebral hemorrhage is a devastating disease. Despite its clinical importance, the
pathophysiology of intracerebral hemorrhage is not well understood. Hematoma expansion …

Objective In the wake of intracerebral hemorrhage (ICH), a devastating stroke with no
effective treatment, hemoglobin/iron‐induced oxidative injury leads to neuronal loss and …

Objective Seizures have been implicated as a cause of secondary brain injury, but the
systemic and cerebral physiologic effects of seizures after acute brain injury are poorly …

Measurement of intracranial pressure (ICP) and mean arterial pressure (MAP) is used to
derive cerebral perfusion pressure (CPP) and to guide targeted therapy of acute brain injury …

Intracerebral hemorrhage (ICH) is a devastating condition. Existing preclinical ICH models
focus largely on striatum but neglect other brain areas such as ventricle, cortex, and …

In this study, we examined injury progression after intracerebral haemorrhage (ICH) induced
by collagenase in mice using a preclinical 11.7 Tesla MRI system. On T2-weighted MRI …