Block copolymer micelles in nanomedicine applications
Polymeric micelles are demonstrating high potential as nanomedicines capable of
controlling the distribution and function of loaded bioactive agents in the body, effectively …
controlling the distribution and function of loaded bioactive agents in the body, effectively …
Knocking down barriers: advances in siRNA delivery
In the 10 years that have passed since the Nobel prize-winning discovery of RNA
interference (RNAi), billions of dollars have been invested in the therapeutic application of …
interference (RNAi), billions of dollars have been invested in the therapeutic application of …
Polymeric delivery of therapeutic nucleic acids
R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021 - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …
Ultrafast self-gelling powder mediates robust wet adhesion to promote healing of gastrointestinal perforations
Achieving strong adhesion of bioadhesives on wet tissues remains a challenge and an
acute clinical demand because of the interfering interfacial water and limited adhesive …
acute clinical demand because of the interfering interfacial water and limited adhesive …
Nucleic acid therapeutics using polyplexes: a journey of 50 years (and beyond)
U Lächelt, E Wagner - Chemical reviews, 2015 - ACS Publications
Since the elucidation of the molecular structure of nucleic acids and understanding of their
role in encoding and translating genetic information into biological function, 1 the knowledge …
role in encoding and translating genetic information into biological function, 1 the knowledge …
Cationic polymers and their therapeutic potential
SK Samal, M Dash, S Van Vlierberghe… - Chemical Society …, 2012 - pubs.rsc.org
The last decade has witnessed enormous research focused on cationic polymers. Cationic
polymers are the subject of intense research as non-viral gene delivery systems, due to their …
polymers are the subject of intense research as non-viral gene delivery systems, due to their …
Coacervate‐derived hydrogel with effective water repulsion and robust underwater bioadhesion promotes wound healing
Achieving robust underwater adhesion by bioadhesives remains a challenge due to
interfacial water. Herein a coacervate‐to‐hydrogel strategy to enhance interfacial water …
interfacial water. Herein a coacervate‐to‐hydrogel strategy to enhance interfacial water …
Nanocomplex‐mediated in vivo programming to chimeric antigen receptor‐M1 macrophages for cancer therapy
Chimeric antigen receptor‐T (CAR‐T) cell immunotherapy has shown impressive clinical
outcomes for hematologic malignancies. However, its broader applications are challenged …
outcomes for hematologic malignancies. However, its broader applications are challenged …
Cationic polymers as transfection reagents for nucleic acid delivery
Nucleic acid therapy can achieve lasting and even curative effects through gene
augmentation, gene suppression, and genome editing. However, it is difficult for naked …
augmentation, gene suppression, and genome editing. However, it is difficult for naked …
Polyethylene glycol and polyethylenimine dual‐functionalized nano‐graphene oxide for photothermally enhanced gene delivery
Graphene oxide (GO) has been extensively explored in nanomedicine for its excellent
physiochemical, electrical, and optical properties. Here, polyethylene glycol (PEG) and …
physiochemical, electrical, and optical properties. Here, polyethylene glycol (PEG) and …