Block copolymer micelles in nanomedicine applications

H Cabral, K Miyata, K Osada, K Kataoka - Chemical reviews, 2018 - ACS Publications
Polymeric micelles are demonstrating high potential as nanomedicines capable of
controlling the distribution and function of loaded bioactive agents in the body, effectively …

Knocking down barriers: advances in siRNA delivery

KA Whitehead, R Langer, DG Anderson - Nature reviews Drug …, 2009 - nature.com
In the 10 years that have passed since the Nobel prize-winning discovery of RNA
interference (RNAi), billions of dollars have been invested in the therapeutic application of …

Polymeric delivery of therapeutic nucleic acids

R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021 - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

Ultrafast self-gelling powder mediates robust wet adhesion to promote healing of gastrointestinal perforations

X Peng, X **a, X Xu, X Yang, B Yang, P Zhao… - Science …, 2021 - science.org
Achieving strong adhesion of bioadhesives on wet tissues remains a challenge and an
acute clinical demand because of the interfering interfacial water and limited adhesive …

Nucleic acid therapeutics using polyplexes: a journey of 50 years (and beyond)

U Lächelt, E Wagner - Chemical reviews, 2015 - ACS Publications
Since the elucidation of the molecular structure of nucleic acids and understanding of their
role in encoding and translating genetic information into biological function, 1 the knowledge …

Cationic polymers and their therapeutic potential

SK Samal, M Dash, S Van Vlierberghe… - Chemical Society …, 2012 - pubs.rsc.org
The last decade has witnessed enormous research focused on cationic polymers. Cationic
polymers are the subject of intense research as non-viral gene delivery systems, due to their …

Coacervate‐derived hydrogel with effective water repulsion and robust underwater bioadhesion promotes wound healing

X Peng, Y Li, T Li, Y Li, Y Deng, X **e… - Advanced …, 2022 - Wiley Online Library
Achieving robust underwater adhesion by bioadhesives remains a challenge due to
interfacial water. Herein a coacervate‐to‐hydrogel strategy to enhance interfacial water …

Nanocomplex‐mediated in vivo programming to chimeric antigen receptor‐M1 macrophages for cancer therapy

M Kang, SH Lee, M Kwon, J Byun, D Kim… - Advanced …, 2021 - Wiley Online Library
Chimeric antigen receptor‐T (CAR‐T) cell immunotherapy has shown impressive clinical
outcomes for hematologic malignancies. However, its broader applications are challenged …

Cationic polymers as transfection reagents for nucleic acid delivery

X Cai, R Dou, C Guo, J Tang, X Li, J Chen, J Zhang - Pharmaceutics, 2023 - mdpi.com
Nucleic acid therapy can achieve lasting and even curative effects through gene
augmentation, gene suppression, and genome editing. However, it is difficult for naked …

Polyethylene glycol and polyethylenimine dual‐functionalized nano‐graphene oxide for photothermally enhanced gene delivery

L Feng, X Yang, X Shi, X Tan, R Peng, J Wang, Z Liu - Small, 2013 - Wiley Online Library
Graphene oxide (GO) has been extensively explored in nanomedicine for its excellent
physiochemical, electrical, and optical properties. Here, polyethylene glycol (PEG) and …