Cellular stress induced by the abnormal accumulation of unfolded or misfolded proteins at
the endoplasmic reticulum (ER) is emerging as a possible driver of human diseases …

The clinical manifestation of neurodegenerative diseases is initiated by the selective
alteration in the functionality of distinct neuronal populations. The pathology of many …

The endoplasmic reticulum (ER) is an important organelle involved in protein quality control
and cellular homeostasis. The accumulation of unfolded proteins leads to an ER stress …

The endoplasmic reticulum is responsible for much of a cell's protein synthesis and folding,
but it also has an important role in sensing cellular stress. Recently, it has been shown that …

Stress induced by the accumulation of unfolded proteins in the endoplasmic reticulum (ER)
is a feature of specialized secretory cells and is also observed in many diseases, including …

The spliced form of X-box binding protein 1 (XBP1s) is an active transcription factor that
plays a vital role in the unfolded protein response (UPR). Under endoplasmic reticulum (ER) …

The unfolded protein response (UPR) is a homeostatic mechanism by which cells regulate
levels of misfolded proteins in the endoplasmic reticulum (ER). Although it is well …

The endoplasmic reticulum (ER) is a dynamic intracellular organelle with multiple functions
essential for cellular homeostasis, development, and stress responsiveness. In response to …

Leptin has not evolved as a therapeutic modality for the treatment of obesity due to the
prevalence of leptin resistance in a majority of the obese population. Nevertheless, the …

During prion disease, an increase in misfolded prion protein (PrP) generated by prion
replication leads to sustained overactivation of the branch of the unfolded protein response …