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Frontiers in electrochemical sensors for neurotransmitter detection: towards measuring neurotransmitters as chemical diagnostics for brain disorders
It is extremely challenging to chemically diagnose disorders of the brain. There is hence
great interest in designing and optimizing tools for direct detection of chemical biomarkers …
great interest in designing and optimizing tools for direct detection of chemical biomarkers …
Creating the feedback loop: closed loop neurostimulation
Implantable devices for electrical stimulation of the brain have been in routine clinical use
since 1997, when the first commercial deep brain stimulation (DBS) system was approved …
since 1997, when the first commercial deep brain stimulation (DBS) system was approved …
Deep brain stimulation induced normalization of the human functional connectome in Parkinson's disease
Neuroimaging has seen a paradigm shift away from a formal description of local activity
patterns towards studying distributed brain networks. The recently defined framework of the …
patterns towards studying distributed brain networks. The recently defined framework of the …
A neurochemical closed-loop controller for deep brain stimulation: toward individualized smart neuromodulation therapies
PJ Grahn, GW Mallory, OU Khurram, BM Berry… - Frontiers in …, 2014 - frontiersin.org
Current strategies for optimizing deep brain stimulation (DBS) therapy involve multiple
postoperative visits. During each visit, stimulation parameters are adjusted until desired …
postoperative visits. During each visit, stimulation parameters are adjusted until desired …
Approaches to closed-loop deep brain stimulation for movement disorders
OBJECTIVE Deep brain stimulation (DBS) is a safe and effective therapy for movement
disorders, such as Parkinson's disease (PD), essential tremor (ET), and dystonia. There is …
disorders, such as Parkinson's disease (PD), essential tremor (ET), and dystonia. There is …
WINCS Harmoni: Closed-loop dynamic neurochemical control of therapeutic interventions
There has been significant progress in understanding the role of neurotransmitters in normal
and pathologic brain function. However, preclinical trials aimed at improving therapeutic …
and pathologic brain function. However, preclinical trials aimed at improving therapeutic …
Cortico-striatal circuits: Novel therapeutic targets for substance use disorders
It is widely believed that substance use disorder (SUD) results from both pre-alterations
(vulnerability) and/or post-alterations (drug effects) on cortico-striatal circuits. These circuits …
(vulnerability) and/or post-alterations (drug effects) on cortico-striatal circuits. These circuits …
Defining a path toward the use of Fast-scan cyclic voltammetry in human studies
Fast Scan Cyclic Voltammetry (FSCV) has been used for decades as a neurochemical tool
for in vivo detection of phasic changes in electroactive neurotransmitters in animal models …
for in vivo detection of phasic changes in electroactive neurotransmitters in animal models …
3-Tesla MRI in patients with fully implanted deep brain stimulation devices: a preliminary study in 10 patients
OBJECTIVE The aim of this study was to evaluate the safety of 3-T MRI in patients with
implanted deep brain stimulation (DBS) systems. METHODS This study was performed in 2 …
implanted deep brain stimulation (DBS) systems. METHODS This study was performed in 2 …
Real-time dopamine measurement in awake monkeys
Fast-scan cyclic voltammetry (FSCV) is often used to measure real-time dopamine (DA)
concentrations in awake, behaving rodents. Extending this technique to work in monkeys …
concentrations in awake, behaving rodents. Extending this technique to work in monkeys …