An overview of cancer treatment modalities
Cancer is a global issue majorly affecting develo** countries. According to a survey, 63%
of deaths due to cancer are reported from develo** countries. There are different …
of deaths due to cancer are reported from develo** countries. There are different …
Protein degradation: expanding the toolbox to restrain cancer drug resistance
Despite significant progress in clinical management, drug resistance remains a major
obstacle. Recent research based on protein degradation to restrain drug resistance has …
obstacle. Recent research based on protein degradation to restrain drug resistance has …
Lynch syndrome, molecular mechanisms and variant classification
Patients with the heritable cancer disease, Lynch syndrome, carry germline variants in the
MLH1, MSH2, MSH6 and PMS2 genes, encoding the central components of the DNA …
MLH1, MSH2, MSH6 and PMS2 genes, encoding the central components of the DNA …
The deubiquitinase USP10 regulates KLF4 stability and suppresses lung tumorigenesis
Krüppel-like factor 4 (KLF4), a key transcription factor, acts as a multifunctional player
involved in the progression of numerous aggressive cancers. The proteasome-dependent …
involved in the progression of numerous aggressive cancers. The proteasome-dependent …
LINC00240 in the 6p22.1 risk locus promotes gastric cancer progression through USP10-mediated DDX21 stabilization
N Zhang, B Wang, C Ma, J Zeng, T Wang, L Han… - Journal of Experimental …, 2023 - Springer
Background Gastric cancer remains the leading cause of cancer death in the world. It is
increasingly evident that long non-coding RNAs (lncRNAs) transcribed from the genome …
increasingly evident that long non-coding RNAs (lncRNAs) transcribed from the genome …
Deubiquitylating enzymes in cancer and immunity
J Ren, P Yu, S Liu, R Li, X Niu, Y Chen… - Advanced …, 2023 - Wiley Online Library
Deubiquitylating enzymes (DUBs) maintain relative homeostasis of the cellular ubiquitome
by removing the post‐translational modification ubiquitin moiety from substrates. Numerous …
by removing the post‐translational modification ubiquitin moiety from substrates. Numerous …
Deubiquitinating enzymes: Promising targets for drug resistance
Highlights•Drug resistance towards chemotherapy and molecularly targeted therapies
remains a great challenge in cancer treatments.•Deubiquitinating enzymes (DUBs) regulate …
remains a great challenge in cancer treatments.•Deubiquitinating enzymes (DUBs) regulate …
Understanding how mismatch repair proteins participate in the repair/anti-recombination decision
Mismatch repair (MMR) systems correct DNA mismatches that result from DNA polymerase
misincorporation errors. Mismatches also appear in heteroduplex DNA intermediates formed …
misincorporation errors. Mismatches also appear in heteroduplex DNA intermediates formed …
Oncogene-induced senescence mediated by c-Myc requires USP10 dependent deubiquitination and stabilization of p14ARF
Oncogene-induced senescence (OIS) is a critical tumor-suppressor mechanism, which
prevents hyper-proliferation and transformation of cells. c-Myc promotes OIS through the …
prevents hyper-proliferation and transformation of cells. c-Myc promotes OIS through the …
The USP10-HDAC6 axis confers cisplatin resistance in non-small cell lung cancer lacking wild-type p53
Abstract Ubiquitin-specific peptidase 10 (USP10) stabilizes both tumor suppressors and
oncogenes in a context-dependent manner. However, the nature of USP10's role in non …
oncogenes in a context-dependent manner. However, the nature of USP10's role in non …