Spin hyperpolarization in modern magnetic resonance

J Eills, D Budker, S Cavagnero, EY Chekmenev… - Chemical …, 2023 - ACS Publications
Magnetic resonance techniques are successfully utilized in a broad range of scientific
disciplines and in various practical applications, with medical magnetic resonance imaging …

Tumor imaging using hyperpolarized 13C magnetic resonance spectroscopy

KM Brindle, SE Bohndiek, FA Gallagher… - Magnetic resonance …, 2011 - Wiley Online Library
Dynamic nuclear polarization is an emerging technique for increasing the sensitivity of
magnetic resonance imaging and spectroscopy, particularly for low‐γ nuclei. The technique …

Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research

J Kurhanewicz, DB Vigneron, K Brindle… - Neoplasia, 2011 - Elsevier
A major challenge in cancer biology is to monitor and understand cancer metabolism in vivo
with the goal of improved diagnosis and perhaps therapy. Because of the complexity of …

Development of methods and feasibility of using hyperpolarized carbon‐13 imaging data for evaluating brain metabolism in patient studies

I Park, PEZ Larson, JW Gordon… - Magnetic resonance …, 2018 - Wiley Online Library
Purpose Hyperpolarized carbon‐13 (13C) metabolic imaging is a noninvasive imaging
modality for evaluating real‐time metabolism. The purpose of this study was to develop and …

Accelerated MR spectroscopic imaging—a review of current and emerging techniques

W Bogner, R Otazo, A Henning - NMR in Biomedicine, 2021 - Wiley Online Library
Over more than 30 years in vivo MR spectroscopic imaging (MRSI) has undergone an
enormous evolution from theoretical concepts in the early 1980s to the robust imaging …

IDEAL spiral CSI for dynamic metabolic MR imaging of hyperpolarized [1‐13C]pyruvate

F Wiesinger, E Weidl, MI Menzel… - Magnetic resonance …, 2012 - Wiley Online Library
Abstract Metabolic imaging with hyperpolarized [1‐13C] pyruvate offers the unique
opportunity for a minimally invasive detection of cellular metabolism. Efficient and robust …

Advanced magnetic resonance spectroscopic neuroimaging: Experts' consensus recommendations

AA Maudsley, OC Andronesi, PB Barker… - NMR in …, 2021 - Wiley Online Library
Magnetic resonance spectroscopic imaging (MRSI) offers considerable promise for
monitoring metabolic alterations associated with disease or injury; however, to date, these …

Investigation of analysis methods for hyperpolarized 13C‐pyruvate metabolic MRI in prostate cancer patients

PEZ Larson, HY Chen, JW Gordon, N Korn… - NMR in …, 2018 - Wiley Online Library
MRI using hyperpolarized (HP) carbon‐13 pyruvate is being investigated in clinical trials to
provide non‐invasive measurements of metabolism for cancer and cardiac imaging. In this …

Fast dynamic 3D MR spectroscopic imaging with compressed sensing and multiband excitation pulses for hyperpolarized 13C studies

PEZ Larson, S Hu, M Lustig, AB Kerr… - Magnetic resonance …, 2011 - Wiley Online Library
Hyperpolarized 13C MR spectroscopic imaging can detect not only the uptake of the pre‐
polarized molecule but also its metabolic products in vivo, thus providing a powerful new …

Rapid multislice imaging of hyperpolarized 13C pyruvate and bicarbonate in the heart

AZ Lau, AP Chen, NR Ghugre… - Magnetic resonance …, 2010 - Wiley Online Library
Hyperpolarization of spins via dynamic nuclear polarization (DNP) has been explored as a
method to non‐invasively study real‐time metabolic rocesses occurring in vivo using 13C …