Pre-eclampsia

LC Chappell, CA Cluver, S Tong - The Lancet, 2021 - thelancet.com
Pre-eclampsia is a multisystem pregnancy disorder characterised by variable degrees of
placental malperfusion, with release of soluble factors into the circulation. These factors …

Preeclampsia: pathophysiology, challenges, and perspectives

S Rana, E Lemoine, JP Granger… - Circulation …, 2019 - Am Heart Assoc
Hypertensive disorders of pregnancy—chronic hypertension, gestational hypertension, and
preeclampsia—are uniquely challenging as the pathology and its therapeutic management …

The 2021 International Society for the Study of Hypertension in Pregnancy classification, diagnosis & management recommendations for international practice

LA Magee, MA Brown, DR Hall, S Gupte… - Pregnancy …, 2022 - Elsevier
All units managing hypertensive pregnant women should maintain and review uniform
departmental management protocols and conduct regular audits of maternal & fetal …

Pre-eclampsia: pathogenesis, novel diagnostics and therapies

EA Phipps, R Thadhani, T Benzing… - Nature Reviews …, 2019 - nature.com
Pre-eclampsia is a complication of pregnancy that is associated with substantial maternal
and fetal morbidity and mortality. The disease presents with new-onset hypertension and …

Hypertensive disorders of pregnancy: ISSHP classification, diagnosis, and management recommendations for international practice

MA Brown, LA Magee, LC Kenny, SA Karumanchi… - …, 2018 - Am Heart Assoc
4. There are significant long-term cardiovascular risks for women with chronic hypertension
and those who have had gestational hypertension or preeclampsia. One initial …

Tracking placental development in health and disease

JD Aplin, JE Myers, K Timms… - Nature Reviews …, 2020 - nature.com
Pre-eclampsia and fetal growth restriction arise from disorders of placental development and
have some shared mechanistic features. Initiation is often rooted in the maldevelopment of a …

[HTML][HTML] Imbalances in circulating angiogenic factors in the pathophysiology of preeclampsia and related disorders

S Rana, SD Burke, SA Karumanchi - American journal of obstetrics and …, 2022 - Elsevier
Preeclampsia is a devastating medical complication of pregnancy that can lead to significant
maternal and fetal morbidity and mortality. It is currently believed that there is abnormal …

Predictive value of the sFlt-1: PlGF ratio in women with suspected preeclampsia

H Zeisler, E Llurba, F Chantraine… - … England Journal of …, 2016 - Mass Medical Soc
Background The ratio of soluble fms-like tyrosine kinase 1 (sFlt-1) to placental growth factor
(PlGF) is elevated in pregnant women before the clinical onset of preeclampsia, but its …

Pre-eclampsia

BWJ Mol, CT Roberts, S Thangaratinam, LA Magee… - The Lancet, 2016 - thelancet.com
Summary Pre-eclampsia affects 3–5% of pregnancies and is traditionally diagnosed by the
combined presentation of high blood pressure and proteinuria. New definitions also include …

The classification, diagnosis and management of the hypertensive disorders of pregnancy: a revised statement from the ISSHP

AL Tranquilli, G Dekker, L Magee, J Roberts… - … An International Journal …, 2014 - Elsevier
There has never been a definite consensus on the classification and diagnostic criteria for
the hypertensive disorders of pregnancy. This uncertainty is likely to have led to between …